山东医药2016，Vol.56Issue(17)：5-8,4.DOI:10.3969/j.issn.1002-266X.2016.17.002
钾通道开放剂尼可地尔对冠心病Warm-up 现象及 HRR 的影响
Effect of a KATP channel opener nicorandil on Warm-up phenomenon and HRR
摘要
Abstract
Objective To investigate the effects of nicorandil which is a KATP channel opener on the warm-up phe-nomenon and the changes of heart rate recovery ( HRR) after sequential exercise test in patients with coronary artery disease. Methods Seventy-five patients with chronic stable angina who had positive exercise and were angiographically proved that the stenosis degree was 70-90% in at least one major branch were selected.They were divided into the control group with conventional treatment (25cases), nicorandil group which was treated by the conventional treatment +5 mg nicorandil, three times a day (25cases) and the isosorbide mononitrate group which was treated by the conventional treatment +20 mg isosor-bide mononitrate, twice a day (25cases).All of them underwent two cycles of exercise tests (EX1 and EX2) with interval of 15 min.We observed the ischaemic threshold values ( the corresponding heart-rate systolic blood pressure, RPP) , the time of reducing 0.1 mV ST-segment depression (T-STD), maximum STD (STD max), the recovery time to 0.05 mV ST-segment depression, whole exercise duration (ED) and the changes of HRR within and between the three groups.Results When we compared EX1 and EX2 among these three groups, each index of EX2 was improved as compared with that of EX1 ( P<0.05).Compared with the control group, only STDmax was improved better in the isosorbide mononitrate group (P<0.05). The changes of RPP, T-STD, the recovery time to 0.05 mV ST depression and STDmax in the nicorandil group were better than those of the control group and the isosorbide mononitrate group (P<0.05 or P<0.01).There was significant difference in HRR between EX1 and EX2 (P<0.01), as well as between the nicorandil group and the control group (P<0.05).Con-clusions Nicorandil promotes the occurrence of the warm-up phenomenon, and KATP channel may be as an important mech-anism involved in the warm-up phenomenon.Meanwhile, nicorandil is beneficial to HRR.关键词
冠心病/尼可地尔/Warm-up现象/钾通道/运动试验/心率恢复Key words
coronary heart disease/nicorandil/Warm-up phenomenon/potassium channels/exercise test/heart rate recovery分类
医药卫生引用本文复制引用
郑梅,李立卓,姜志安,李丽宏,梁芸,刘金波..钾通道开放剂尼可地尔对冠心病Warm-up 现象及 HRR 的影响[J].山东医药,2016,56(17):5-8,4.基金项目
石家庄市科技研究与发展指导计划项目（141462993）。 （）
