山东医药2016，Vol.56Issue(17)：19-21,3.DOI:10.3969/j.issn.1002-266X.2016.17.006
不同放疗时机对诱导化疗的局限型 NSCLC患者疗效、免疫功能及预后的影响
Effects of different radiotherapy timing on outcomes of limited-stage non-small-cell lung cancer with induction chemotherapy
摘要
Abstract
Objective To study the effects of different timing of radiotherapy on the clinical efficacy, immune function and prognosis of patients with limited-stage non-small-cell lung cancer ( NSCLC) by induction chemotherapy.Methods Ninety-six cases of limited-stage NSCLC who received combination therapy of NP chemotherapy and radiotherapy were se-lected.They were divided into 3 groups (A, B, C) randomly according to the different initial time of radiotherapy.Pa-tients in the groups A, B and C started to receive the radiotherapy after 0, 2 and 5 cycles of NP chemotherapy, respective-ly.The clinical efficacy, adverse reactions and immune function ( CD3 +, CD4 +, CD8 +and NK cell percentage) of the three groups were compared, and Kaplan-Meier was used to estimate the survival curve about prognosis of patients in the three groups.Results The total effective rates of groups A, B and C were 77.4%, 62.5%and 46.9%respectively, and significant difference was found between and among these three groups (all P<0.05).The adverse reaction rates of three groups also had significant difference (all P<0.05).The cell percentage of CD3+, CD4 +, CD8 +and NK in the three groups was significantly lower than that before treatment, and the most significant decline was found in the group A ( all P<0.05) .The difference of survival rate between groups A and B was not significant, but they were both higher than that of group C (all P<0.05).Conclusion As the prolonged time of radiation, the curative effect of patients with limited-stage NSCLC is decreased and the prognosis is poor, but its effect on immune function was relatively less.关键词
肺肿瘤/化学疗法/放射疗法/免疫功能Key words
lung carcinoma/chemotherapy/radiotherapy/immune function分类
医药卫生引用本文复制引用
王巍,刘冉生,张爱旭,袁智勇..不同放疗时机对诱导化疗的局限型 NSCLC患者疗效、免疫功能及预后的影响[J].山东医药,2016,56(17):19-21,3.基金项目
国家自然科学基金资助项目（81472797）。 （）
