中国组织工程研究2016，Vol.20Issue(11)：1630-1636,7.DOI:10.3969/j.issn.2095-4344.2016.11.017
细胞膜片技术在组织工程中的应用与研究进展
Application of cell sheet technology in tissue engineering
摘要
Abstract
BACKGROUND:The cel sheet technology that is applied with the absence of scaffolds and enzymatic digestion can effectively repair tissue defects and improve organ function, by stimulating the secretion of extracelular matrix to form a dense membrane tissue. <br> OBJECTIVE: To review the recent progress in cel sheet technology used in tissue engineering, thereby providing a new idea for relevant basic and clinical research. <br> METHODS:The first author retrieved CNKI database, Wanfang database and PubMed with the keywords of “cel sheet, tissue engineering” in Chinese and English, respectively. Literature retrieval period was from January 2010 to July 2015. <br> RESULTS AND CONCLUSION:Cel sheet technology combined with scaffold materials can be used for reconstruction and repair of tissues and organs. With the emerging of new technologies, multi-layer cel sheets are stratified to form a three-dimensional tissue for repair of soft tissues and organs. Compared with the monolayer cel sheet, the three-dimensional cel sheet that is laminated by same or different cel sheets has stronger regenerative ability and can be used to construct the ideal target tissue modelin vitro. Cel sheet technology combined with scaffolds can improve the mechanical strength of the composite and reduce cel loss, which has made great progress in the repair of tooth, bone and cartilage tissue. Currently, the cel sheet technology is at the laboratory stage, and little is reported on its clinical applications. We look forward to more innovative technologies that can be integrated into the cel sheet technology.关键词
组织构建/组织工程/细胞膜片技术/再生医学/血管化/国家自然科学基金Key words
Path-Clamp Techniques/Regenerative Medicine/Neovascularization, Physiologic分类
医药卫生引用本文复制引用
周术奎,张楷乐,王营,傅强..细胞膜片技术在组织工程中的应用与研究进展[J].中国组织工程研究,2016,20(11):1630-1636,7.基金项目
2012国家自然科学基金面上项目(81270780)负载VEGF的磁性量子点结合细胞膜片技术构建组织工程尿道的实验研究Funding:the National Natural Science Foundation of China in 2012, No.81270780 （81270780）
