中国组织工程研究2016，Vol.20Issue(12)：1725-1731,7.DOI:10.3969/j.issn.2095-4344.2016.12.008
聚羟基丁酸酯-羟基戊酸酯/溶胶-凝胶生物活性玻璃促进牙周组织再生
Poly(hydroxybutyrate-co-hydroxyvalerate)-sol-gel bioactive glass promotes periodontal tissue regeneration
孙文娟 1许艺川 2黄南楠 1唐倩 1陈翠婷1
作者信息
- 1. 中山大学附属第三医院 口腔科，广东省广州市 510630
- 2. 中山大学附属第三医院 血液科，广东省广州市 510630
- 折叠
摘要
Abstract
BACKGROUND:Our previous studies have shown that the poly(hydroxybutyrate- co-hydroxyvalerate) - sol-gel bioactive glass (PHBV-SGBG) has good biocompatibility and promote bone tissue repair, but its specific role in periodontal tissue regeneration has not been investigated. OBJECTIVE:To investigate the periodontal regenerative effects of a PHBV-SGBG scaffold in beagle dogs. METHODS:Alveolar bone defects (5 mm×5 mm) were surgicaly created bilateraly at the buccal side of the mandibular third and fourth premolars of four beagle dogs. PHBV-SGBG scaffold was randomly filed in the defects as experimental group and nothing was put into the contralateral as control group. Histological and scanning electron microscopy observations, cone-beam CT evaluation and the Ca/P concentration ratio analysis were processed at 2, 4, 8 and 12 weeks after surgery. RESULTS AND CONCLUSION:After surgery, the height of the regenerated tissue increased with time in both groups, and the regenerated tissue height in the experiment group was higher than that in the control group (P < 0.05). At 12 weeks after surgery, the Ca/P concentration ratio of the experiment group was close to that in the normal tissue (P > 0.05), but higher than that of the control group (P < 0.05); the histological observation showed that the regenerated tissue of the experimental group was close to the normal tissue, and the regenerated tissue of the control group tended to be mature, with a smal amount of new blood vessels. Under the scanning electron microscope, no scaffold structure was visible in the experimental group with the presence of bone lacuna at 8 weeks after surgery, while in the control group, there was no bone lacuna and obvious osteoblasts; at 12 weeks after surgery, the structure of the regenerated tissue of experimental group was more regular and close to the normal tissue with no remarkable osteoblasts, and in the control group, the regenerated tissue was disordered, with several cavity. These results show that the PHBV-SGBG scaffold can enhance periodontal bone regeneration effectively.关键词
生物材料/口腔生物材料/聚羟基丁酸酯-羟基戊酸酯/溶胶-凝胶生物活性玻璃/组织工程支架/牙周组织再生分类
医药卫生引用本文复制引用
孙文娟,许艺川,黄南楠,唐倩,陈翠婷..聚羟基丁酸酯-羟基戊酸酯/溶胶-凝胶生物活性玻璃促进牙周组织再生[J].中国组织工程研究,2016,20(12):1725-1731,7.
