现代医药卫生2016，Vol.32Issue(7)：972-974,977,4.DOI:10.3969/j.issn.1009-5519.2016.07.004
免疫杀伤细胞治疗对恶性肿瘤患者调节性T细胞的影响
Effect of immune killer cells therapy on regulatory T cells in patients with malignant tumor
摘要
Abstract
Objective To investigate the effect of immune killer cells therapy on CD4+CD25+CD127LOW and CD8+CD28-regulatory T cells in the patients with malignant tumor. Methods Fifty patients with malignant tumor treated by the immune killer cells therapy in the oncology department of our hospital from May 2011 to April 2014 were taken as the research subjects (tumor group) and 30 individuals undergoing the healthy physical examination were selected as the control group. Flow cytometry was used to detect the peripheral blood CD4+CD25+CD127LOW and T regulatory CD4+cells with CD8+CD28-and CD8+. Results The peripheral blood CD4+CD25+CD127LOW/CD4+and CD8+CD28-/CD8+before treatment in the tumor group were 11.48%±1.44%and 19.69%±5.01%,which were significantly higher than 4.65%±0.75%and 15.35%±4.71%in the control group,the differences were statistically significant(P<0.05). The peripheral blood CD4+CD25+CD127LOW/CD4+and CD8+CD28-/CD8+after treatment in the tumor group were 5.55%±0.81%and 16.15%±4.61%,which were significantly lower than before treatment with statistical differ-ences;but slightly higher than those in the control group without statistical differences (P>0.05). Conclusion Immune killer cells in treating malignant tumor can reduce the peripheral blood CD4+CD25+CD127LOW,CD8+CD28-regulatory T cells level,corrects the immune imbalance state and improves the immune function.关键词
杀伤细胞/T淋巴细胞,调节性/肿瘤/抗原,CD4/抗原,CD8/抗原,CD28/流式细胞术Key words
Killer cells/T-lymphocytes,regulatory/Neoplasms/Antigens,CD4/Antigens,CD8/Antigens, CD28/Flow cytometry引用本文复制引用
韩兆东,阮月芹,韩晓通,梁葵香,孙其静,李卫..免疫杀伤细胞治疗对恶性肿瘤患者调节性T细胞的影响[J].现代医药卫生,2016,32(7):972-974,977,4.基金项目
滨州医学院科技计划项目（BY2012KJ13）。 （）
