摘要
Abstract
Objective To observe the left thyroxin sodium piece ( Euthyrox) in the treatment of hypothyroidism dur-ing pregnancy ( hypothyrea) on thyroid function and the outcome of the pregnancy.Methods 100 patients with hypothyroid-ism during pregnancy were selected in Department of Obstetrics and Gynecology, Wuchang Hospital of Wuhan City from Feb-ruary 2014 to March 2015.They were randomly divided into observation group and control group, 50 cases for each group . The observation group was treated with Euthyrox, while the control group received conventional treatment.Pregnancy outcomes and the level changes of TSH, FT3 , FT4 , TPOAb in both groups were compared.Results After treatment, the TSH, FT3 , FT4 , TPOAb were significantly improved as compared with those before treatment in both groups.[ The observation group :(3.1 ±0.9) μU/ml vs.(7.2 ±1.4) μU/ml, (13.5 ±1.7) pmol/L vs.(10.0 ±1.9) pmol/L, (3.2 ±0.5) pmol/L vs. (2.3 ±0.9) pmol/L, (52.8 ±12.5) U/ml vs.(182.0 ±71.2) U/ml.The control group:(5.1 ±0.8)μU/ml vs.(7.4 ± 1.5)μU /ml,(11.3 ±1.6)pmol/L vs.(9.9 ±1.9)pmol/L,(3.0 ±0.4)pmol/L vs.(2.2 ±0.9)pmol/L,(96.5 ±10.4)U/ml vs.(182.3 ±73.5)U/ml], that’s a statistically significant difference compared with before treatment ( P <0.05).And the total incidence of the pregnancy complications in the observation group was 28.0%less than 78.0%in the control group. The total incidence of adverse perinatal outcomes was 8.0%, significantly lower than 28.0%in the control group, the differ-ences above between the two groups were significant ( P <0.05).Conclusion Pregnancy women with hypothyroidism trea-ted with Euthyrox can effectively improve the level of TSH, FT3 , FT4 content, reduce the occurrence of adverse pregnancy out-comes, and achieve significant therapeutic effect.关键词
妊娠期/甲状腺功能减退症/优甲乐Key words
Pregnancy/Hypothyroidism/Euthyrox
