Abstract
Objective To study the effects of low molecular heparin calcic on the renal function, blood coagulation function index and blood pressure in the treatment of pregnancy patients with preeclampsia.Methods Seventy-two pregnancy patients with preeclampsia in our hospital from January 2013 to August 2015 were divided into observation group and control group according to the draw method, 36 cases in each group.Control group were given magnesium sulfate, on the basis of con-trol group, the observation group were treated combined with heparin calcium.The renal function, blood coagulation function, blood pressure, pregnancy outcome of the two groups were compared.Results The concentration of serum creatinine, urea ni-trogen concentration of the two groups of patients had no obvious difference before and after treatment.After treatment, blood uric acid, urine protein quantitation of observation group were obviously lower than the control group[(235.24 ±10.21)μmol/L vs.(305.16 ±12.12)μmol/L, (0.87 ±0.08)g/24h vs.(1.26 ±0.45)g/24h, P <0.05], which was a statisti-cally significant difference ( P <0.05), and thrombin time (TT), activated partial prothrombin time (APTT) were longer than the control group[(15.26 ±2.12)s vs.(13.54 ±1.67)s, (38.75 ±3.56)s vs.(35.26 ±3.42)s, P <0.05],but platelet volume ( MPV) , platelet count ( PLT) , fibrinogen ( Fbg) , prothrombin time ( PT) had no significant change in the two groups before and after treatment ( P >0.05).After treatment, the systolic and diastolic blood pressure of the observa-tion group were respectively (141 ±18) mmHg, (92 ±9)mmHg ,and in the control group were respectively (142 ±17) mm-Hg, (93 ±8) mmHg, lower than before treatment ( P <0.05), but there was no significant difference between two groups ( P >0 .05) .There were no differences in the incidence of delivery cycle, neonatal body quality, the incidence of fetal dis-tress, neonatal mortality, rate of placental abruption, incidence rate of postpartum hemorrhage, fetal growth restriction be-tween the two groups( P >0.05), but the Apgar score≥7 in the observation group was 88.89% (32/36), higher than the control group 66.67%(24/36), while cesarean section rate was 13.89% (5/36) , lower than the control group 36.11%(13/36), with a statistical significance difference ( P <0.05).Conclusion Low molecular heparin calcic, which belong to the safe and effective drugs, will not affect the maternal blood pressure, can improve kidney and blood coagulation functions and will not increase maternal and infant risk.关键词
妊娠子痫/低分子肝素钙/肾功能/凝血功能/妊娠结局Key words
Preeclampsia/Low molecular heparin/Renal function/Blood coagulation function/Pregnancy outcome
