中国临床药理学杂志2016，Vol.32Issue(6)：486-488,3.DOI:10.13699/j.cnki.1001-6821.2016.06.002
不同年龄对阿替普酶静脉溶栓治疗急性脑梗死的临床疗效和预后的影响
Effect of different age on the clinical efficacy and prognosis of acute cerebral infraction patients treated by intravenous thrombolytic therapy with alteplase
谢江文 1吕国菊 2郑珍婕 1宋晓明 1毛玲群 3董伟4
作者信息
- 1. 宁波鄞州第二医院 神内科，浙江宁波 315200
- 2. 宁波鄞州第二医院 心血管内科，浙江宁波 315200
- 3. 台州市中心医院神经内科，浙江台州 31800
- 4. 宁波余姚市人民医院神经内科，浙江宁波 315400
- 折叠
摘要
Abstract
Objective To analysis the effect of different age factor on the prognosis and efficacy of acute cerebral infraction in patients treated by intravenous thrombolytic therapy with alteplase.Methods Ninety-eight patients with cerebral infarction were divided into older group (n=52) and younger group(n=46).Patients in two groups were trea-ted by intravenous thrombolysis with 0.9 mg · kg-1 alteplase.After 1 and 21 d, the efficacy was observed and scored using national institute of health stroke scale( NIHSS).At the same time,the incidence of adverse drug reactions were observed, and prognosis evaluated using Modified Rankin scale ( mRS ) in 3 weeks.Results NIHSS scores were signifi-cantly lower in the both groups treated by alteplase than those before thera-py( P<0.05).In 1 and 21 d, NIHSS scores were lower in the younger groups than those in elderly group ( P<0.05 ).The incident of adverse drug reaction was lower in the younger groups than the elderly group ( P<0.05).It has shown that the prognosis was better in the younger group than the elderly group ( P<0.05 ) by comparing mRS score in 3 weeks.Conclusion All acute cerebral infraction patients received sig-nificant benefits from the intravenous thrombolytic therapy with alteplase.The younger group had more significant efficacy, less complications and better prognosis than those of elderly group.关键词
阿替普酶/静脉溶栓/年龄/脑梗死/预后Key words
alteplase/intravenous thrombolysis/age/prognosis分类
医药卫生引用本文复制引用
谢江文,吕国菊,郑珍婕,宋晓明,毛玲群,董伟..不同年龄对阿替普酶静脉溶栓治疗急性脑梗死的临床疗效和预后的影响[J].中国临床药理学杂志,2016,32(6):486-488,3.
