中国临床药理学杂志2016，Vol.32Issue(6)：489-491,3.DOI:10.13699/j.cnki.1001-6821.2016.06.003
复方丹参滴丸联合阿托伐他汀钙治疗2型糖尿病合并颈动脉硬化的临床疗效及安全性评价
Clinical efficacy and safety of Danshen dripping pill combined with atorvastatin calcium in the treatment of type 2 diabetic mellitus with carotid atherosclerosis
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of Dan-shen dripping pill combined with atorvastatin calcium in the treatment of type 2 diabetic mellitus with carotid atherosclerosis.Methods Ninety patients of type 2 diabetic mellitus with carotid atherosclerosis were randomly divided into control group ( n =40 ) and treatment group ( n=50 ).Patients in the control group were treated with atorvastatin cal-cium 10 mg, once per night for 3 months.Patients in the treatment group were treated with Danshen dripping pill 270 mg, tid combined with ator-vastatin calcium 10 mg, once per night for 3 months.The clinical effica-cy, blood lipid, vascular endothelial function, bilateral carotid intima-media thickness, plaque area, and adverse drug reactions were compared between two groups.Results After treatment, total effective rate in treatment group was significantly higher than that in control group (92.00% vs 82.50%, P<0.05 ).By comparison with control group, the blood lipid levels in treatment group was significantly lower, vascular endothelial function was improved, bilateral carotid plaque area and ca-rotid intima -media thickness were significantly lower ( P <0.05 ).There were no adverse drug reactions occurred between two groups during the treatment.Conclusion Danshen dripping pill combined withatorvastatin calcium can significantly decreases the level of blood-lipid, improve the symptom of carotid atherosclerosis and the endothelial function for the type 2 diabetic mellitus patients.关键词
复方丹参滴丸/阿托伐他汀钙/2型糖尿病/颈动脉硬化/内皮功能Key words
Danshen dripping pill/atorvastatin calcium/type 2 diabetic mellitus/carotid atherosclerosis/endothelial function分类
医药卫生引用本文复制引用
史丽,李明霞,王立坤,刘俊峰,宁改君,任卫东..复方丹参滴丸联合阿托伐他汀钙治疗2型糖尿病合并颈动脉硬化的临床疗效及安全性评价[J].中国临床药理学杂志,2016,32(6):489-491,3.基金项目
河北省张家口市科技局2012指导性基金资助项目 （）
