中国临床药理学杂志2016，Vol.32Issue(6)：495-498,4.DOI:10.13699/j.cnki.1001-6821.2016.06.005
白细胞介素－17在慢性乙型病毒性肝炎及肝硬化患者中的表达及意义比较
Expression and comparison of significance of interleukin -17 in patients with chronic hepatitis B and hepatitis B virus cirrhosis
摘要
Abstract
Objective To investigate the expression and compare the significance of interleukin-17 ( IL-17 ) A-F in patients with chronic hepatitis B ( CHB) and hepatitis B virus ( HBV) cirrhosis.Methods The stools and serum samples of 66 patients with CHB and 50 patients with HBV cirrhosis were collected, and the serum samples of 30 healthy volunteers were collected.HBV DNA in stool and serum were detected by real -time quantitative polymerase chain reaction ( PCR ) .IL-17A-F, IL-1β, IL-6 and CXC chemokine ligand 13 ( CXCL-13) were detected by ELISA.Liver function was detected by automatic bio-chemical analyzer.Results The expression of serum IL -17 A -F in patients with CHB or HBV cirrhosis were significantly higher than those in healthy volunteers ( P <0.01 ) , but no difference between patients with CHB and cirrhosis (P>0.05).In patients with CHB, IL-17A-F were positively correlated with IL-1β, IL-6 and CXCL-13, and ne-gatively correlated with total bilirubin.IL-17C was positively correlated with total bile acid.IL-17B, IL -17D and IL -17E were positivelycorrelated with stool HBV DNA.In patients with HBV cirrhosis, IL -17B was positively correlated with IL -1β.IL-17C was positively correlated with aspartate aminotransferase and alkaline phosphatase.IL-17D was positively correlated with alkaline phosphatase.IL -17 A -F had no correlation with serum HBV DNA and stool HBV DNA ( P>0.05) .Conclusion There were high expressions of serum IL -17A -F in patients with CHB and HBV cirrhosis, but the clinical significance of IL-17A-F was different.关键词
慢性乙型病毒性肝炎/乙型病毒性肝炎肝硬化/白细胞介素-17/乙型病毒性肝炎病毒DNA/细胞因子Key words
chronic hepatitis B/hepatitis B virus cirrhosis/interleukin-17/hepatitis B virus DNA/cytokine分类
医药卫生引用本文复制引用
郑吉顺,陈萌萌,周翔天,刘艳艳,李家斌..白细胞介素－17在慢性乙型病毒性肝炎及肝硬化患者中的表达及意义比较[J].中国临床药理学杂志,2016,32(6):495-498,4.基金项目
国家自然科学基金资助项目 （）
