中国临床药理学杂志2016，Vol.32Issue(6)：499-501,3.DOI:10.13699/j.cnki.1001-6821.2016.06.006
马来酸曲美布汀联合舒肝颗粒治疗功能性消化不良的临床疗效及安全性评价
Clinical efficacy and safety of trimebutine combined with Shugan granule in the treatment of functional dyspepsia
于惠玲 1鲁素彩 1孟杰 1王阳阳 1常颖 1门路 1高蕊 1丁静1
作者信息
- 1. 河北大学 附属医院 消化科，河北 保定071000
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of tri-mebutine combined with Shugan granule in the treatment of functional dyspepsia.Methods A total of 84 patients with functional dyspepsia were randomly divided into control group ( n=42 ) and treatment group ( n=42 ).Control group was treated with trimebutine 0.2 g, tid for 4 weeks.Treatment group was treated with trimebutine 0.2 g, tid and Shu-gan granule 3 g, bid for 4 weeks.The clinical symptom scores, self -rating anxiety scale ( SAS ) and self -rating depression scale ( SDS ) scores, and incidence of adverse drug reactions were compared between the two groups.Results After treatment, the clinical symptom scores, SAS and SDS scores in treatment group were significantly lower than those in control group( all P<0.05).The incidence of adverse drug reactions in two groups has no significant difference( P>0.05).Conclusion The combined therapy of trimebutine and Shugan granule can significantly improve the clinical symptoms and the states of anxiety and depression without increasing of the incidence of adverse drug reactions.关键词
马来酸曲美布汀/舒肝颗粒/功能性消化不良/临床疗效/安全性Key words
trimebutine/Shugan granule/functional dyspepsia/clinical efficacy/safety分类
医药卫生引用本文复制引用
于惠玲,鲁素彩,孟杰,王阳阳,常颖,门路,高蕊,丁静..马来酸曲美布汀联合舒肝颗粒治疗功能性消化不良的临床疗效及安全性评价[J].中国临床药理学杂志,2016,32(6):499-501,3.
