中国临床药理学杂志2016，Vol.32Issue(6)：508-510,3.DOI:10.13699/j.cnki.1001-6821.2016.06.009
奥沙利铂联合5－氟尿嘧啶治疗中晚期食管癌的临床疗效及安全性评价
Clinical efficacy and safety of oxaliplatin combined with 5 -fluorouracil in the treatment of advanced esophageal cancer
佘明金 1马祖胜 1李桂芝 1朱文博 1程蒙蒙 1秦高明1
作者信息
- 1. 武警安徽总队医院肿瘤科，合肥 230041
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of oxaliplatin combined with 5 -fluorouracil ( 5 -FU ) in the treatment of advanced esophageal cancer.Methods Sixty -five patients with advanced esophageal cancer were randomly divided into control group (n=32) and treatment group(n=33).The patients in two groups were treated with conventional fractionated radiotherapy at 2.0 Gy, with a total dose of 56-66 Gy.Chemotherapy was delivered on the first day of radio-therapy.Control group was received 52.5 mg · m-2 · d -1 cisplatin on day 1 +500 mg · m-2 · d -1 5 -Fu on day 1 -5 through intravenous drip.Treatment group was received 85-100 mg · m-2 · d-1 oxaliplatin through intravenous infusion two hours on day 1 +500 mg · m -2 · d -1 5-FU on day 1 -5 through intravenous drip.Every 4 weeks was a cycle, all received two cycles of chemotherapy.The clinical efficacy and incidence of adverse drug reactions between two groups were compared.Results After treatment, total effective rates were 81.80% and 75.00%in treatment group and control group, disease control rates were 96.97% and 93.75% in treatment group and control group, one year survival rates were 77.30%and 68.20%in treatment group and control group, with no statistical difference between the two groups( P>0.05).After treatment, the occurrence rate of nausea and vomiting in treatment group was signifi-cantly lower than that in control group(34.60%vs 62.50%, P<0.05) .The occurrence rate of sensory neuropathy in treatment group was significantly higher than that in control group(24.00%vs 0, P<0.05).Conclusion Concurrent chemoradiation with oxaliplatin and 5-FU for the treatment of advanced esophageal cancer exhibited a definitive clini-cal efficacy with clinical manageable adverse drug reactions.关键词
食管癌/奥沙利铂/5-氟尿嘧啶/临床疗效/安全性Key words
esophageal cancer/oxaliplatin/5-fluorouracil/clinical efficacy/safety分类
医药卫生引用本文复制引用
佘明金,马祖胜,李桂芝,朱文博,程蒙蒙,秦高明..奥沙利铂联合5－氟尿嘧啶治疗中晚期食管癌的临床疗效及安全性评价[J].中国临床药理学杂志,2016,32(6):508-510,3.
