中国临床药理学杂志2016，Vol.32Issue(6)：523-525,3.DOI:10.13699/j.cnki.1001-6821.2016.06.014
血浆谷氨酸与γ－氨基丁酸水平对麻醉后幼儿早期认知功能障碍的相关性研究
Study on the correlation between plasma lutamate and gamma aminobutyric acid levels and early cognitive function after anesthesia with propofol or etomidate
摘要
Abstract
Objective To observe the effects of propofol or etomidate an-esthesia on early cognitive function in infant with laparoscopic hernia re-pair and its influence on the content changes of glutamate ( GLU ) and gamma aminobutyric acid ( GABA) in plasma, and explore the correla-tion between plasma glutamate and glutamate levels and early cognitive function after anesthesia with propofol or etomidate.Methods One hun-dred cases of 1-3 years pediatric patients, scheduled for elective laparo-scopic hernia neoplasty, were divided into propofol anesthesia group (group A), etomidate anesthesia group (group B), 50 cases in each;50 cases of the same age healthy children as control group ( group C ).A, B groups were given propofol anesthesia induction of 1-3 mg· kg -1 , 0.1-0.4 mg· kg-1 etomidate.The changes of GLU, GABA content of patients in the cognitive dysfunction group and non post operative cogni-tive dysfunction group were compared within A, B groups or between them.Results The number of postoperative cognitive dysfunction inA and B groups were 10 (20.0%) and 9 cases (18.0%, P>0.05) , respectively.Compared with the preoperative B and A group, there was a slight increase of GLU and GABA in the patients with non post-operative cognitive dysfunc-tion, and the difference had no statistically significant ( P>0.05 ) , but the contents of them had obvious increase in postoperative cognitive dysfunction group ( P<0.05 ).The elevation of GLU and GABA had a positive correlation with the occurrence of cognitive dysfunction.Conclusion The levels of GLU and GABA in plasma can indirectly reflect the brain injury degrees of infants after anesthesia, which could be used as a detective index for the incidence of cognitive dysfunction in early postoperative infants.关键词
幼儿/丙泊酚/依托咪酯/谷氨酸/γ-氨基丁酸/术后认知功能障碍Key words
infant/propofol/etomidate/glutamic acid/gamma-aminobutyric acid/postoperative cognitive dysfunction分类
医药卫生引用本文复制引用
蒋奕红,谢景远,熊威威,李爱国,黄志华,彭凌云..血浆谷氨酸与γ－氨基丁酸水平对麻醉后幼儿早期认知功能障碍的相关性研究[J].中国临床药理学杂志,2016,32(6):523-525,3.基金项目
广西高校学校科研基金资助项目（201204lx243）；桂林市科学研究与技术开发基金资助项目 （）
