中国临床药理学杂志2016，Vol.32Issue(6)：529-530,552,3.DOI:10.13699/j.cnki.1001-6821.2016.06.016
新疆地区维吾尔族血浆同型半胱氨酸水平与亚甲基四氢叶酸还原酶 C677 T基因多态性的关联性分析
Correlation between plasma homocysteine levels and methylenetetrahydrofolate reductase C677T gene polymorphism in Uygur population of Xinjiang region
贾莉 1吴建华 1于鲁海 1李红健 1王婷婷 1玛尔江 1蒋玉凤1
作者信息
- 1. 新疆维吾尔自治区人民医院 药学部，乌鲁木齐 830001
- 折叠
摘要
Abstract
Objective To explore the correlation between hyperhomo-cysteinemia ( HCY ) and methylenetetrahydrofolate reductase C677 T (MTHFRC677T) gene polymorphism in Uygur nationality of Xinjiang region.Methods A total of 117 patients of Uygur nationality were selected and divided into 2 groups according to the level of HCY 15μmol· L-1.C677T polymorphism in MTHFR gene and plasma HCY le-vel were detected.Results There were statistically significant difference between plasma homocysteine levels and MTHFRC677T gene type in Xinjiang Uygur nationality.Patients of hyperhomocysteinemia with TT genotypes of MTHFRC677T was significantly more than that those with CC or CT genotypes.Conclusion The MTHFRC677T genetic variant may be a predictor of hyperhomocysteinemia risk in Xinjiang Uygur population.关键词
血浆同型半胱氨酸/亚甲基四氢叶酸还原酶( MTHFR) C677T基因多态性/维吾尔族人群/关联性Key words
plasma homocysteine/methylenetetrahydrofolate reductase C677 T gene polymorphism/Uygur population/correlation分类
医药卫生引用本文复制引用
贾莉,吴建华,于鲁海,李红健,王婷婷,玛尔江,蒋玉凤..新疆地区维吾尔族血浆同型半胱氨酸水平与亚甲基四氢叶酸还原酶 C677 T基因多态性的关联性分析[J].中国临床药理学杂志,2016,32(6):529-530,552,3.
