中国临床药理学杂志2016，Vol.32Issue(7)：582-584,3.DOI:10.13699/j.cnki.1001-6821.2016.07.002
神经节苷酯钠治疗急性重症颅脑损伤的临床疗效研究
Clinical efficacy of ganglioside in treatment of acute severe craniocerebral injury
摘要
Abstract
Objective To evaluate the clinical efficacy of early applica-tion of ganglioside in the treatment of acute severe craniocerebral injury, and to put forward nursing measures.Methods Ninety cases of patients with acute severe craniocerebral injury were randomly divided into control group (n=45) and treatment group (n=45).Control group was given the treatment of 5 mL· kg-1 20%mannitol, 30 min infusion is comple-ted, 0.4 mg· kg -1 furosemide, naloxone 8 mg, Xingnaojing injection 20 mL, hemocoagulase 1 kU, continuous treatment for 8 weeks.Treatment group was given ganglioside injection 100 mg, continuous treatment for 2 weeks, and reduced the dose to 40 mg for maintenance therapy at next 6 weeks.The inflammatory factor, coagulation function and prognosis of two groups were compared between two groups.Results After treat-ment, calcitonin gene -related peptide in treatment group was signifi-cantly higher than that of control group, tumor necrosis factor-α, endo-thelin -l were significantly lower than those of control group ( P<0.05) .Thrombin time of treatment group was significantly lower than that of control group, fibrinogen was significantly higher than that of control group ( P <0.05 ) , the differences of platelets, prothrombin time, activated partial thromboplastin time and other indicators between two groups were not statistically significant ( P>0.05 ).Good prognosis rate in treatment group was significantly higher than that of control group ( 46.67% vs 22.22%, P <0.05 ).Conclusion Ganglioside helps to alleviate inflammatory symptoms, improve coagulation function, and improve the effect of treatment.Strengthening the nursing intervention can effectively improve the prognosis of patients.关键词
急性重症颅脑损伤/神经节苷酯钠/炎性因子/凝血功能Key words
acute severe craniocerebral injury/ganglioside/inflammatory factor/coagulant function分类
医药卫生引用本文复制引用
周婷,张平,张莉,宋凌霞,李大芬,贺建湘,冯翼..神经节苷酯钠治疗急性重症颅脑损伤的临床疗效研究[J].中国临床药理学杂志,2016,32(7):582-584,3.基金项目
贵州省科学技术基金资助项目 （）
