中国临床药理学杂志2016，Vol.32Issue(7)：588-590,3.DOI:10.13699/j.cnki.1001-6821.2016.07.004
枸橼酸咖啡因在早产儿原发性呼吸暂停中的临床研究
Clinical effect of caffeine citrate on primary premature apnea in premature infants
赵强 1宋红 2李志洁3
作者信息
- 1. 郑州大学 第二附属医院 儿科，郑州 450003
- 2. 郑州大学 第二附属医院 新生儿科，郑州 450003
- 3. 郑州大学 第二附属医院 儿童保健科，郑州 450003
- 折叠
摘要
Abstract
Objective To evaluate the effect of caffeine citrate on pri-mary premature apnea in premature infants.Methods Ninety premature infants with primary premature apnea were divided into treatment group and control group.Premature infants in control group were treated by loading dose of 5 mg· kg -1 of amnophyllinea, maintaining doses of 2.5 mg· kg-1.Premature infants in treatment group were treated by loading dose of 20 mg· kg-1 of caffeine citrate, maintaining doses of 5 mg· kg-1.The treatment lasted for 5 days.Effective rate,the disappearance time of clinical symptoms, length of hospital, expense and mortality between 2 groups were analyzed and compared before and after treatment.Results The effective rate of treatment group was 95.2%, which was higher than that of control group (77.0%, P<0.05).Compared with the con-trol group, the disappearance time of clinical symptoms, hospitalization time and the expenses in treatment group was significantly lower ( P<0.05).While mortality in treatment group is lower than that of con-trol group, but there was no statistical difference between two groups ( P>0.05).Conclusion The short course of caffeine citrate on premature infants with primary premature apnea has better effects without obvious adverse drug reaction, and finally relieves patients’ financial burden.关键词
早产儿/原发性呼吸暂停/短疗程/枸橼酸咖啡因/氨茶碱Key words
primary apnea/premature infants/the short course/caffeine citrate/aminophylline分类
医药卫生引用本文复制引用
赵强,宋红,李志洁..枸橼酸咖啡因在早产儿原发性呼吸暂停中的临床研究[J].中国临床药理学杂志,2016,32(7):588-590,3.
