中国临床药理学杂志2016，Vol.32Issue(7)：603-605,3.DOI:10.13699/j.cnki.1001-6821.2016.07.009
奥曲肽治疗恶性肠梗阻早期炎症的临床疗效及安全性评价
Clinical efficacy and safety of octreotide in the treatment of early postoperative inflammation of malignant bowel obstruction
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of oc-treotide in the treatment of early postoperative inflammation of malignant bowel obstruction with.Methods Sixty-eight patients with early post-operative inflammation of malignant bowel obstruction were randomly di-vided into control group (n=34) and treatment group (n=34).Control group was received dexamethasone 5 mg intravenously, q8 h, gradual withdrawal after 1 week.Treatment group was treated with octreotide 0.1 mg subcutaneous injection q8 h on the basic treatment of control group, until the gastrointestinal exhaust, defecation and other functions returned to normal or transit surgery only to be discontinued.The clinical efficacy, signs of improvement time, situation of laboratory examinations and inci-dence of adverse drug reactions were compared between two groups.Results After treatment, total effective rate in treatment group was higher than that of control group ( 94.12% vs 64.71%, P <0.05 ).After treatment, the improvement time of clinical symptoms and signs for bloating, abdominal pain, nausea, vomiting and defecation flatus in treatment group was shorter than that of control group ( P<0.05).After treatment, the two groups of decompression volume and C -reactiveprotein were lower than those before treatment ( P<0.05) , and degree drop of treatment group was better than that in control group ( P<0.05).The time of correcting water and electrolyte and acid-base balance and X-ray examina-tion showed normal time in treatment group were lower than that in control group ( P<0.05).There were no collected serious adverse drug reactions in two groups during the treatment.Conclusion Octreotide has a definitive clinical efficacy for the treatment of early postoperative inflammation of malignant bowel obstruction, and has no significant adverse drug reactions.关键词
奥曲肽/恶性肠梗阻/早期炎症/临床疗效/安全性Key words
octreotide/malignant bowel obstruction/early inflammatory/clinical research分类
医药卫生引用本文复制引用
梁启新,汪晓明,于庆生..奥曲肽治疗恶性肠梗阻早期炎症的临床疗效及安全性评价[J].中国临床药理学杂志,2016,32(7):603-605,3.基金项目
2010年度安徽中医学院临床科学研究基金资助项目 （）
