中国临床药理学杂志2016，Vol.32Issue(7)：612-614,3.DOI:10.13699/j.cnki.1001-6821.2016.07.012
靶控输注舒芬太尼对心脏二尖瓣置换术患者麻醉质量的影响
Effect of target controlled infusion of sufentanil on the anesthesia quality in patients with heart mitral valve replacement
摘要
Abstract
Objective To investigate the influence of target controlled in-fusion of sufentanil on anesthesia quality in patients with heart mitral valve replacement.Methods The 60 patients with mitral valve replace-ment were randomly divided into control group ( n=30 ) and treatment group ( n=30 ).Anesthesia of patients in treatment group was induced and maintained using target-controlled infusion sufentanil at effect-site concentration of 0.8 ng · mL-1 and 0.4-0.8 ng · mL-1 ) , respective-ly.Anesthesia of patients in control group was induced by intravenous in-fusion of 10 μg · kg-1 sufentanil and maintained by injection of 10μg· kg -1 fentanyl.Extubation time after surgery, recovery time, visual analog scale ( VAS) score at extubation time, postoperative hemodyna-mics and the incidence of adverse drug reactions were compared between two groups.Results After surgery, the recovery and extubation time in the treatment group was significantly shorter than that in control group ( P<0.05).After surgery, VAS score between the two groups were not statistically significant ( P >0.05 ).After surgery, the mean arterial pressure, blood pressure, oxygen saturation in the treatment group were significantly higher ( P<0.05 ).The incidence of adverse drug reactions of treatment group was significantly lower than that in control group ( P<0.05 ).Conclusion For the patients with mitral valve replacement surgery, the treatment of target controlled infusion of sufentanil has a high anesthesia quality, rapid recovery and small adverse drug reactions.关键词
舒芬太尼/二尖瓣置换术/麻醉/安全性Key words
sufentanil/mitral valve replacement/anesthesia/safety分类
医药卫生引用本文复制引用
高珲,邵永丰..靶控输注舒芬太尼对心脏二尖瓣置换术患者麻醉质量的影响[J].中国临床药理学杂志,2016,32(7):612-614,3.基金项目
江苏省“六大人才高峰”基金资助项目 （）
