中国临床药理学杂志2016，Vol.32Issue(8)：684-686,3.DOI:10.13699/j.cnki.1001-6821.2016.08.004
依托咪酯静脉维持麻醉对乳腺癌手术患者术后苏醒质量的影响
Effects of intravenous anesthesia maintained by etomidate on recovery quality in breast cancer patients undergoing radical mastectomy
摘要
Abstract
Objective To evaluate the effects of etomidate used for maintenance of intravenous anesthesia on recovery quality in breast can-cer patients undergoing radical mastectomy. Methods Sixty breast cancer patients scheduled to receive radical mastectomy were randomly divi-ded into treatment group and control group, 30 patients in each group.Anesthesia was maintained by continuous infusion of etomidate 10-15 μg・ kg -1・ min-1 in treatment group, or propofol 6 -8 mg・ kg-1・ h-1 in control group.In two groups, open eyes time, extuba-tion time and orientation recovery time were observed.The hemodynamics indexes during extubation period and adverse drug reactions such as nau-sea, vomiting were also recorded.Results There were no statistical differences about open eyes time and extubation time in all patients of the two groups ( P >0.05 ) .During extubation period of anesthesia, treat-ment group could keep relatively stable hemodynamics, but the diffe-rences had no statistically significant between two groups.In treatment group, the incidence of nausea and vomiting was significantly higher than that of control group ( P<0.05).Conclusion In radical mastectomy of breast cancer patients, application of etomidate combined with remifen-tanil for anesthesia maintenance has shorter extubation time, hemodyna-mic stability and satisfactory recovery quality from intravenous anesthesia.It proves that intravenous anesthesia maintained by etomidate in short-time surgery is safe and feasible.关键词
依托咪酯/瑞芬太尼/静脉麻醉/苏醒质量Key words
etomidate/remifentanil/intravenous anesthesia/quality of recovery分类
医药卫生引用本文复制引用
何欣,赵洪伟,李锦成..依托咪酯静脉维持麻醉对乳腺癌手术患者术后苏醒质量的影响[J].中国临床药理学杂志,2016,32(8):684-686,3.基金项目
天津医学会麻醉学分会青年科研培育基金资助项目 （）
