中国临床药理学杂志2016，Vol.32Issue(8)：690-692,3.DOI:10.13699/j.cnki.1001-6821.2016.08.006
辛伐他汀联合通脉颗粒治疗不稳定型心绞痛的临床疗效及安全性评价
Clinical efficacy and safety of simvastatin combined with tongmai particle in the treatment of unstable angina
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of simvastatin combined with tongmai particle in the treatment of unstable angina.Methods The 132 cases of unstable angina were randomly divided into control group(n=66) and treatment group(n=66).Control group was orally received simvastatin 10 -40 mg, qd.Treatment group was oral given tongmai particle 10 mg, tid on the basis of control group. The course of two groups lasted for 4 weeks.The clinical efficacy, angina frequency, duration, hemodynamics and serum lipids, and incidence of adverse drug reactions were compared between two groups.Results After treatment, the clinical efficacy in treatment group was significantly higher than that in control group(93.94%vs 84.85%, P<0.05).The at-tack frequency and duration of angina, levels of hematocrit, whole blood viscosity, fibrinogen, total cholesterol, low -density lipoprotein choles-terol in treatment group were significantly lower than those in control group ( P<0.05).The incidence of adverse drug reactions had no significant difference between two groups ( P >0.05 ) .Conclusion Simvastatin combined with tongmai particle has a definitive clinical efficacy for the treatment of unstable angina, which can effectively alleviate the clinical symptoms, improve blood circulation and blood lipids.关键词
不稳定型心绞痛/辛伐他汀/通脉颗粒/临床疗效/安全性Key words
unstable angina/simvastatin/tongmai particle/clinical efficacy/safety分类
医药卫生引用本文复制引用
赵庆霞,张秀梅,纪征,安浩君..辛伐他汀联合通脉颗粒治疗不稳定型心绞痛的临床疗效及安全性评价[J].中国临床药理学杂志,2016,32(8):690-692,3.基金项目
2011年河北省医学适用技术跟踪项目基金资助项目 （）
