中国临床药理学杂志2016，Vol.32Issue(8)：703-706,4.DOI:10.13699/j.cnki.1001-6821.2016.08.010
水提乌药与醇提乌药对急性酒精性肝损伤模型大鼠的保护作用
Protective effect of the water extract and alcohol extract of Radix Linderae on acute alcoholic liver injury in rats
摘要
Abstract
Objective To observe the protective effect of the water extract and alcohol extract of Radix Linderae on acute alcoholic liver injury in rats.Methods Forty healthy male SD rats were randomly divided into four groups:normal group ( n=10 ) , model group ( n=10 ) , the water extract of Radix Linderae group(WYSTW,n=10),and the alcohol ex-tract of Radix Linderae group (WYCTW,n=10).The normal group was given equal volume of water, while the other groups were given different concentrations of alcohol, twice a day, and company with the WYSTW and WYCTW ( both 1 g・ mL-1 ) for 10 days.Serum total cholesterol (TC), triglyceride ( TG), alanine aminotransferase ( ALT), aspartate aminotransferase ( AST) , serum superoxide dismutase ( SOD) , malondi-aldehyde ( MDA) were measured.The expression of interleukin -1 beta ( IL-1β) , nuclear transfer factor kappa B( NF-κB) and tumor necro-sis factor -α( TNF-α) in liver tissue was observed by immuno histo-chemical method.Results Compared with model group, Radix Linderae extracts can effectively reduce the serum ALT, AST, MDA, TG contents ( P <0.05) ,and effectively increase the SOD activity in serum and liver tissue ( P <0.05).WYSTW and WYCTW can improve liver tissue pathological change and control expression of IL-1β, NF -κB, TNF -αin liver cells.Conclusion WYSTW and WYCTW have the protective effect on acute alcoholic liver injury in rats and have the effect of anti-inflammatory and anti-oxidation.关键词
乌药/醇提取物/水提取物/肝损伤/核转录因子-κBKey words
Radix Linderae/alcohol extract/water extract/liver injury/nuclear factor kappa B分类
医药卫生引用本文复制引用
汤小刚,洪汝涛..水提乌药与醇提乌药对急性酒精性肝损伤模型大鼠的保护作用[J].中国临床药理学杂志,2016,32(8):703-706,4.基金项目
浙江省中医药局基金资助项目（2008CA117）；浙江省科技厅公益性技术应用研究计划基金资助项目（2013C33222）；浙江省医药卫生科技计划基金资助项目 （）
