中国临床药理学杂志2016，Vol.32Issue(8)：707-709,3.DOI:10.13699/j.cnki.1001-6821.2016.08.011
大鼠神经病理痛模型的两种不同制备方法效果比较
Comparison the effect of the two models of neuropathic pain
摘要
Abstract
Objective To establish the chronic constriction injury model (CCI)rat model by catgut(group A)and by catgut including the needle ( group B) and compare the effects of two methods.Methods Fourty-five SD rats were randomized into sham-operated group, group A and group B.The mechanical with drawl threshold( MWT) and thermal with drawl latency( TWL) were measured to detect the effect of CCI rat model on the day of 7, 9, 11, 13, 15, 17, 19, 21 after operation.Results The mechanical and thermal pain threshold in group A and group B were both lower than those in sham -operated group ( P <0.01 ) , which showed the success of CCI model.The success rate in group B was higher than that in group A and the mechanical with drawl threshold significantly decreased than that in group A ( P<0.01).Conclusion The rat model of neuropathic pain could be prepared by two methods, but group B were significantly better than group A.关键词
神经病理痛/动物模型/坐骨神经压迫损伤Key words
neuropathic pain/rat model/constriction injury of the sciatic nerve分类
医药卫生引用本文复制引用
王向东,万丽萍,李晴,张晓丹,周洁,刘曾旭..大鼠神经病理痛模型的两种不同制备方法效果比较[J].中国临床药理学杂志,2016,32(8):707-709,3.基金项目
国家自然科学基金资助项目（81260190）；江西省卫生厅科技计划基金资助项目 （）
