中国临床药理学杂志2016，Vol.32Issue(8)：730-732,3.DOI:10.13699/j.cnki.1001-6821.2016.08.018
抗菌药物药代动力学－药效学模型用于优化五水头孢唑林钠的给药方案
Dosing regimen selection for cefazolin sodium pentahydrate based on its pharmacokinetic/pharmacodynamic analysis
崔晓红 1李德强 1王姝云 2初阳3
作者信息
- 1. 河北医科大学 第二医院 药学部，石家庄050000
- 2. 山西医科大学 第二医院 药学部，太原 030001
- 3. 中国医科大学附属第一医院药学部，沈阳 110001
- 折叠
摘要
Abstract
Objective To explore the rationality of the used dosage of cefazolin sodium pentahydrate in the treatment of infections.Methods The pharmacodynamic data ( MIC ) was obtained from the preclinical studies.The pharmacokinetic data from the phaseⅠclinical research tri-als and published protein binding were varied according to lognormal and uniform distributions.A Monte Carlo simulation (10,000 subjects) esti-mated the cumulative fraction of response ( CFR) at f%T>MIC=50%for intravenous cefazolin sodium pentahydrate 0.25-3.0 g every 6-24 h.Results With the dosage of CFR≥90% as the optimal dosage regi-men, the lowest dosage for treating common infection was 1.0 g bid, 0.75 g tid and 0.5 qid, respectively.Conclusion Based on its pharma-cokinetic/pharmacodynamic characteristics, safety and cost effect, the appropriate dosing regimen of cefazolin sodium pentahydrate injection was 1.5-2.0 g every 12 h for mild and moderate infection, for serious infec-tion the dose can increase to 3.0 g every 12 h or follow doctors’ advices.关键词
五水头孢唑林钠/蒙特卡洛模拟/给药方案Key words
cefazolin sodium pentahydrate/Monte Carol simulation/dosing regimen分类
医药卫生引用本文复制引用
崔晓红,李德强,王姝云,初阳..抗菌药物药代动力学－药效学模型用于优化五水头孢唑林钠的给药方案[J].中国临床药理学杂志,2016,32(8):730-732,3.
