中国社区医师2016，Vol.32Issue(13)：9-10,2.DOI:10.3969/j.issn.1007-614x.2016.13.2
松酯醇二葡萄糖苷对大鼠脑缺血再灌注损伤保护作用机制的研究
Study on the protective effect of pinoresinol diglucoside on cerebral ischemia reperfusion injury in rats
王强 1赵冬梅2
作者信息
- 1. 264003滨州医学院基础医学院
- 2. 256300山东省高青县人民医院
- 折叠
摘要
Abstract
Objective:To investigate the protective effects and mechanism of pinoresinol diglucoside on cerebral ischemia reperfusion injury in Wistar rats.Methods:48 Wistar rats were randomly divided into the sham operation group,cerebral ischemia reperfusion injury model group,high dose of PD group,low dose of PD group.The sham operation group was the same with other groups,but not for clipping.The model group,high dose and low dose of PD groups were divided into two groups after 45 mins since occuring cerebral ischemia,then the rats in the two groups were executed at 2h and 24h respectively after ischemia-reperfusion. Results:Compared with the sham operation group,the content of MDA in brain tissue of the model group was increased significantly,while the activity of SOD decreased significantly(P<0.05);the content of MDA in brain tissue of the high dose and low dose of PD groups decreased significantly when compared with the model group,and also the SOD activity significantly increased(P<0.05).Conclusion:Pinoresinol diglucoside can reduces cerebral ischemia-reperfusion injury in rats by increasing free radical scavenging rate and anti lipid peroxidation.关键词
松脂醇二葡萄糖苷/脑缺血再灌注损伤/抗氧化剂/自由基Key words
Pinoresinol diglucoside/Cerebral ischemia reperfusion injury/Antioxidant/Free radical引用本文复制引用
王强,赵冬梅..松酯醇二葡萄糖苷对大鼠脑缺血再灌注损伤保护作用机制的研究[J].中国社区医师,2016,32(13):9-10,2.
