中国比较医学杂志2016，Vol.26Issue(4)：68-71,4.DOI:10.3969/j.issn.1671-7856.2016.04.012
猕猴全结肠内镜检查方法与观察
Performance and colonoscopic observation in macaques
摘要
Abstract
Diarrhea is a common intestinal symptom in macaque.The corresponding intestinal lesions of macaque are mainly described at autopsy but less observed by colonoscopy.The aim of this study was to develop a colonoscopic technique and to obtain endoscopic images of the entire colon in macaques.Eight healthy adult macaques ( 5 males and 3 females) without diarrhea for 2 months, were fed Glauber’ s salt through nasogastric tubes.The colon cleanliness was well matched to the endoscopic observation of macaque colon.The procedure took 10-20 min for each animal.There was no obvious abnormality in the colon of four animals except some slight differences of mucosal structure from that of human beings.Small pieces of erosion and ulcer in the colons were observed in four macaques which presented mild diarrhea for less than 1 day, while a severe stenosis was observed in one of those four macaques.No animal died during and one week after the endoscopic procedure.Colonoscopy may safely performed in macaques.The images taken by colonoscopy may be important to establish diagnosis and treatment of colitis in macaques in time and to evaluate the efficacy of drug intervention as well.This technique is also helpful to provide qualified macaques for scientific researches.关键词
猕猴/结肠内镜/结肠清洁度/内镜结肠图像/腹泻Key words
Macaque/Colonoscopy/Colon cleanliness/Endoscopic image, colon/Diarrhea分类
医药卫生引用本文复制引用
黄志寅,胡兵,唐承薇,谭庆华,张琼英,王玉芳,冯哲,赵旭东,吕龙宝,陈文雄,唐川君,龚慧..猕猴全结肠内镜检查方法与观察[J].中国比较医学杂志,2016,26(4):68-71,4.基金项目
国家自然科学基金国家（地区）合作与交流项目GZ1065。 （）
