中国比较医学杂志2016，Vol.26Issue(4)：79-82,4.DOI:10.3969/j.issn.1671-7856.2016.04.015
小胶质细胞极化在多发性硬化发病中的作用机制研究进展
Advances in research of the role of microglia polarization in the mechanisms of pathogenesis of multiple sclerosis
摘要
Abstract
Multiple sclerosis ( MS) is an autoimmune disease of the central nervous system ( CNS) characterized by demyelination and inflammation lesions.MS predominantly affects young adults with a high incidence of disability. However, the exact pathogenesis of MS is still not clear.Studies found that microglia polarization tending to pro-inflammatory M1-like state during the onset of MS, causing the M1/M2 ratio imbalance, forming pro-inflammatory microenvironment state, and which further leading to nervous tissue damage ultimately.Microglia polarization may be considered as the initiator of pathologic alterations by releasing pro-inflammatory cytokines and secondarily trigger the initial microglia response.Given the pivotal role of imbalanced microglia polarization in MS initiation, a critical review of microglia polarization is presented here, in order to elucidate the pathogenesis of MS and highlight the noteworthy candidate therapeutic targets for clinic treatment.关键词
小胶质细胞极化/多发性硬化/中枢炎症反应Key words
Microglia polarization/Multiple sclerosis/Central inflammatory reaction/Pathogenesis/Treatment分类
医药卫生引用本文复制引用
张明,刘江红,洪浩,尹琳琳..小胶质细胞极化在多发性硬化发病中的作用机制研究进展[J].中国比较医学杂志,2016,26(4):79-82,4.基金项目
国家自然科学基金项目（81273497，81301208），北京市卫生系统高层次卫生技术人才－学科骨干（2014－3－052）。 （）
