中国医学前沿杂志（电子版）2016，Vol.8Issue(3)：89-92,4.
利巴韦林联合聚乙二醇干扰素α-2a治疗慢性丙型肝炎临床效果分析
Clinical study on the effect of PEG interferon α-2a combined with ribavirin in the treatment of chronic hepatitis C
李远勤 1刘全艳 1于毅 1赵毅1
作者信息
- 1. 达州市中心医院 感染科，四川 达州635000
- 折叠
摘要
Abstract
ObjectiveTo observe the clinical effect of PEG interferon α-2a combined with ribavirin in the treatment of chronic hepatitis C.Method96 cases of chronic hepatitis C patients in our hospital were selected and according to a random number table method they were divided into two groups. Control group patients were treated by routine treatment and ribavirin, observation group patients were treated with ribavirin combined with PEG interferon α-2a injection therapy. Two groups of patients were treated for 24 weeks. HCV antibodies in serum and HCV RNA levels of patients were measured when the two groups were treated for 12 weeks, 24 weeks, 48 weeks after treatment, liver function and effects of the two groups were observed, and adverse events were counted.ResultThe proportion of ETVR and SVR in observation group were signiifcantly higher than control group (P<0.05). After treatment, the levels of ALT and AST in the two groups were lower than before treatment, and the indexes of observation group were lower than control group (P<0.05). And the levels of HA、PCⅢ、CⅣ and LN in the two groups were lower than before treatment, the indexes of observation group were significantly lower than control group (P<0.05). There was no signiifcant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion Ribavirin combined with PEG interferon α-2a injection can be effective in the treatment of chronic hepatitis C, decreased HCV RNA levels in patients and it is safe and important in clinical.关键词
利巴韦林/聚乙二醇干扰素α-2a/慢性丙型肝炎/HCV抗体Key words
Ribavirin/PEG interferon α-2a/Chronic hepatitis C/HCV antibodies引用本文复制引用
李远勤,刘全艳,于毅,赵毅..利巴韦林联合聚乙二醇干扰素α-2a治疗慢性丙型肝炎临床效果分析[J].中国医学前沿杂志（电子版）,2016,8(3):89-92,4.
