中国中医药信息杂志2016，Vol.23Issue(5)：20-23,4.DOI:10.3969/j.issn.1005-5304.2016.05.006
复方参鹿颗粒治疗肾阳虚型再生障碍性贫血疗效观察及对CD4+T细胞亚群的影响
Efficacy Observation ofFufang Shenlu Granule for Kidney-yang Deficiency Aplastic Anemia and Its Effects on CD4+ T Lymphocyte Subsets
摘要
Abstract
Objective To observe the clinical efficacy ofFufang Shenlu Granule for kidney-yang deficiency aplastic anemia (AA) and its effects on CD4+ T lymphocyte subsets, and explore its mechanism.Methods Forty AA patients were randomly divided into treatment group and control group, 20 cases in each group. The treatment group was treated withFufang Shenlu Granule combined with conventional western medicine therapy, while the control group was only treated with conventional western medicine therapy. The treatment lasted for 6 months, and follow-up visits lasted for at least one year. The clinical efficacy and T lymphocyte subsets ratio changes before and after treatment in the two groups were observed.Results The clinical efficacy of treatment group was better than that of control group (P<0.05). After treatment, the blood cell counts of the two groups were improved than those of before treatment (P<0.05,P<0.01). After treatment, the red blood cell count and hemoglobin of treatment group were higher than those of control group (P<0.05). Compared with the data before treatment in treatment group, the ratio of CD4+CD25+ cells in all CD4+ cells, and the ratio of CD4+CD25+FoxP3+ cells in all CD4+CD25+ cells increased (P<0.05); the ratio of Th1 and Th2 cells in all CD3+CD4+ decreased (P<0.05). The ratio of Th2 cells was lower than that before treatment in the control group (P<0.05).ConclusionFufang Shenlu Granule can enhance the treatment efficiency of AA with kidney-yang deficiency syndrome. The mechanism may be related to the decrease of Th1 cells, the increase of CD4+CD25+Tregs and their FoxP3 expression.关键词
复方参鹿颗粒/再生障碍性贫血/CD4+T细胞亚群Key words
Fufang Shenlu Granule/aplastic anemia/CD4+ T lymphocytes subsets分类
医药卫生引用本文复制引用
赵琳,邱仲川,陈珮,黄中迪,胡晓莹,朱小勤,瞿玮颖..复方参鹿颗粒治疗肾阳虚型再生障碍性贫血疗效观察及对CD4+T细胞亚群的影响[J].中国中医药信息杂志,2016,23(5):20-23,4.基金项目
上海市进一步加快中医药事业发展三年行动计划 （）
