中国中医药信息杂志2016，Vol.23Issue(5)：24-27,4.DOI:10.3969/j.issn.1005-5304.2016.05.007
补肾法对慢性乙型肝炎病毒携带者肝组织病理的影响
Effect of Tonifying Kidney Therapy on Pathology of Chronic Hepatitis B Virus Carriers
摘要
Abstract
Objective To study the effects of tonifying kidney therapy on pathology in chronic hepatitis B virus carriers.MethodsWith the multi-center, randomized, double-blinded and placebo-controlled methods, 600 cases of chronic hepatitis B virus carriers were divided intoBushen Qingtou group,Bushen Jianpi group and control group, 200 cases in each group, and were treated withBushen Qingtou prescription,Bushen Jianpi prescription and placebo prescription respectively for 52 weeks. The pathological changes of the liver biopsy were observed by liver biopsy examination before and after treatment. Inflammatory active degree and fibrosis were scored with Knodell HAI and Ishak.Results The number of decreasing more than 2 points on Knodell HAI inBushen Qingtou group,Bushen Jianpi group and control group was 21, 18, and 6 respectively (P<0.05); the number of increasing more than 2 points on Knodell HAI in three groups was 3, 2, and 8 respectively (P<0.05). The curative effect ofBushen Qingtou prescription,Bushen Jianpi prescription were significantly obviously better than control group, without statistical significnce between the two treatment groups (P>0.05). The number of decreasing more than 1 points on Ishak in Bushen Qingtou group,Bushen Jianpi group, and control group was 13, 12, and 9 respectively (P>0.05); the number of increasing more than 1 points on Ishak inBushen Qingtou group,Bushen Jianpi group and control group was 8, 3, and 11 respectively, with statistical significance betweenBushen Jianpi group and controlled group (P<0.01), without statistical significance betweenBushen Qingtou group and control group (P>0.05), which meantBushenJianpi prescription could prevent the deterioration of liver tissue fibrosis more significantly than placebo prescription did. ConclusionTonifying kidney therapy, includingBushen Qingtou prescription andBushen Jianpi prescription, can inhibit the inflammatory activity and slow down the fibrosis progression of the chronic HBV carriers.关键词
慢性乙型肝炎/病毒携带者/肝组织病理/补肾法/临床随机对照试验Key words
chronic hepatitis B/virus carrier/liver pathology/tonifying kidney therapy/RCT分类
医药卫生引用本文复制引用
邢宇锋,童光东,周大桥,贺劲松,魏春山,陈英杰..补肾法对慢性乙型肝炎病毒携带者肝组织病理的影响[J].中国中医药信息杂志,2016,23(5):24-27,4.基金项目
国家科技重大专项 （）
