肿瘤药学2016，Vol.6Issue(2)：89-95,7.DOI:10.3969/j.issn.2095-1264.2016.02.02
脑肿瘤靶向纳米递药系统的研究进展
Recent Advances in Brain Tumor-targeted Nanovehicle Drug Delivery System of Chemotherapeutic Treatments
摘要
Abstract
Malignant tumor is prevalent in brain tumors. Fast growth, difficulty in treatment and poor prognosis resulted in a terrible mortality. When chemotherapeutics penetrate from blood vessels into tumor tissues, there are two obstacles in brain tumor treatment: blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB). Some anti-tumor drugs can not effectively reach into the brain tumor due to the limitation of the physical and chemical properties of these drugs. The targeting strategies are introduced aimed at differentstages of brain tumor development and growth. There are three strate-gies for brain tumor-targeted nanovehicle drug delivery: drug delivery across blood-brain barrier (BBB), blood-brain tumor barrier (BBTB) and enhanced permeability and retention effect (EPR). Many Nanocarriers for drugs were studied such as lipidosome, solid lipid nanoparticles, polymeric micelles, dendrimer, carbon nanotube, polymeric nanoparticles, magnetic nanoparticles and so on. Nanocarriers would localize the therapeutic drugs and enhance retention time at the brain tumor, meanwhile minimize the involvement of peripheral tissues and healthy brain tissue to reduce side effects by controlled par-ticle size and surface modification. Whole-process targeted nano-drug delivery systems according to characteristics of brain tumor growth are expected to be a potential trend for brain cancer treatment.关键词
脑肿瘤/靶向/纳米/给药系统Key words
Brain tumor/Target/Nanovehicles/Drug delivery system分类
医药卫生引用本文复制引用
杜雯雯,吴俊珠,李贵轲,张汉超,张成桂..脑肿瘤靶向纳米递药系统的研究进展[J].肿瘤药学,2016,6(2):89-95,7.基金项目
国家自然科学基金（81360679）；云南省昆虫生物医药研发重点实验室（2015DG030）。 （）
