肿瘤药学2016，Vol.6Issue(2)：103-107,5.DOI:10.3969/j.issn.2095-1264.2016.02.04
DNA 异常甲基化及其在宫颈腺癌中作用的研究进展
Abnormal DNA Methylation in the Development of Cervical Adenocarcinoma
赵雪蘅 1王静 2唐雁 1方凯宁 1赵敏3
作者信息
- 1. 南华大学，湖南 衡阳，421001
- 2. 湖南省肿瘤医院 / 中南大学湘雅医学院附属肿瘤医院，湖南 长沙，410013
- 3. 中南大学湘雅医院临床药理研究所，湖南 长沙，410008
- 折叠
摘要
Abstract
Cancer is a complex disease resulting from genetic and epigenetic abnormality. According to the present researches, epigenetic modification is of practical significance in the occurrence and development of tumors, mainly in the change of DNA methylation, regulation of miRNA expression, histone modifications, activation of oncogene, silence of tumor suppressor genes and so on. Aberrant DNA methylation influences chromatin configuration and expression of oncogene and tumor suppressor genes, thus involving in tumorigenesis. Comprehensive knowledge of the research progress in Cervical Adenocarcinoma DNA methylation could not only make help in early diagnosis of the disease, but also have great clinical value in the targeted treatment and prognosis assessment.关键词
抑癌基因/DNA 甲基化/表观遗传学/宫颈腺癌Key words
Cancer suppressor genes/DNA methylation/Epigenetics/Cervical adenocarcinoma分类
医药卫生引用本文复制引用
赵雪蘅,王静,唐雁,方凯宁,赵敏..DNA 异常甲基化及其在宫颈腺癌中作用的研究进展[J].肿瘤药学,2016,6(2):103-107,5.
