安徽医科大学学报2016，Vol.51Issue(5)：691-695,5.
Graves病131I或抗甲状腺药物治疗前后外周血CD4+CD25+CD127low调节性T细胞的变化
Change of CD4+ CD25+ CD127 low regulatory T cells in peripheral blood of patients with Graves disease treated by 131 I or antithyroid drugs therapy
杨静 1潘天荣 1杜益君 1钟兴1
作者信息
- 1. 安徽医科大学第二附属医院内分泌科，合肥 230601
- 折叠
摘要
Abstract
Objective To investigate the changes of regulatory T cells ( Treg) in Graves disease ( GD) before and after being treated by 131 I or antithyroid drugs( ATD) ,and to seek for new clinical indicators to evaluate the treat-ment response. Methods The study groups included 40 patients with GD ( GD group) , 20 of whom were treated by 131 I ,others were treated by ATD. Forty healthy donors without history of thyroid or autoimmune disease were en-rolled in control group. The proportions of CD4 +CD25 +CD127low Treg , IL-10 and TGF-β1 were tested before and after treatment respectively. Results ① The significant decrease in the proportion of CD4 +CD25 +CD127low Treg cells in untreated GD patients ( GD group) was found compared with the control group;②After treatment of 131 I or ATD, the proportion of Treg was significantly higher than GD group in 3rd and 6th month (P<0. 05); ③ There was no significant difference in the proportion of Treg between ATD group and 131 I group in 3 rd and 6 th month;④The characteristic of cytokine levels(such as IL-10,TGF-β1) was decreased in untreated GD group, and increased after being treated in 6th month (P<0. 05,respectively). There was no significant difference in the cytokine levels between the 131 I group and ATD group at any moment . Conclusion The proportion and function of Treg decrease in GD, but increase in both 131 I and ATD therapy patients. The study shows that Treg may play a critical role in af-fecting immunologic function and prognosis of GD patients.关键词
Graves病/调节性T细胞/碘131/抗甲状腺药物Key words
Graves disease/regulatory T cells/131 I therapy/antithyroid drugs分类
医药卫生引用本文复制引用
杨静,潘天荣,杜益君,钟兴..Graves病131I或抗甲状腺药物治疗前后外周血CD4+CD25+CD127low调节性T细胞的变化[J].安徽医科大学学报,2016,51(5):691-695,5.
