安徽医科大学学报2016，Vol.51Issue(5)：731-734,4.
直肠癌术前容积旋转调强放疗和五野静态调强放疗的剂量学比较
Dosimetric comparison between preoperative volumetric modulated arc therapy and five-field intensity modulated radiotherapy for rectal cancer
摘要
Abstract
Objective To compare the dosimetric characteristics of volumetric modulated arc therapy( VMAT) and five-field intensity modulated radiotherapy(5F-IMRT) in preoperative radiotherapy for rectal cancer. Methods Six-teen patients with rectal cancer who underwent preoperative chemo-radiotherapy were enrolled in this study. VMAT and 5F-IMRT plans were designed for each patient. The dose distribution in target volumes and organs at risk was e-valuated according to the dose-volume histogram. Results Both plans could meet target dose specifications and nor-mal tissue constraint. The CI was similar between the 5F-IMRT(0. 88 ± 0. 04) and VMAT plans (0. 90 ± 0. 03), which could satisfy 95% of prescribed dose for covered PTV. The HI of the VMAT plan was 1. 06 ± 0. 01 compared to 1. 05 ± 0. 01 of IMRT plans,without statistically significant differences(t=1. 37,P>0. 05). There was no signifi-cant difference for the key parameters( Dmean,Dmax) of risk organs such as intestine,bladder and femoral head in the two plans( P>0. 05 ) . There was no significant difference for the key parameters of irradiated volume such as V20,V30, V40 and V50 of risk organs between the 5F-IMRT and VMAT plans(P>0. 05). The VMAT group also had significantly lower number of monitor units(MU)when compared with the 5F-IMRT plan group(P=0. 000). Conclusion The dose distribution of VMAT and 5F-IMRT is similar in preoperative radiotherapy for rectal cancer, and risk organs could be well protected. VMAT offers shorter treatment deliver time than IMRT, reduces treatment MU.关键词
直肠癌/容积弧形调强放射治疗/静态调强放射治疗/剂量学Key words
rectum cancer/volumetric modulated arc therapy/intensity modulated radiotherapy/dosimetry分类
医药卫生引用本文复制引用
汪琳,张红雁,钱立庭,吴爱东,方为,闫冰..直肠癌术前容积旋转调强放疗和五野静态调强放疗的剂量学比较[J].安徽医科大学学报,2016,51(5):731-734,4.基金项目
安徽高校省级自然科学研究项目(编号:KJ2010B380) （编号:KJ2010B380）
