安徽医科大学学报2016，Vol.51Issue(5)：744-747,4.
乌司他丁对严重脓毒症患者远期预后及体内降钙素原的影响
Effect of ulinastatin on serum procalcitonin level and long-term prognosis of severe sepsis patients
摘要
Abstract
Objective To determine the effect of ulinastatin ( UTI) on serum procalcitonin( PCT) level and 60-day prognosis in severe sepsis patients. Methods 151 severe sepsis patients were included in this study. All the patients ( n=151 ) were divided into survival group ( n=84 ) and non-survival group ( n=67 ) , and all the pa-tients (n=151) were also divided into UTI group (n=69) and non-UTI group (n=82). Gender, age, progno-sis, acute physiology and chronic health evaluation Ⅱ ( APACHEⅡ) score, lactate, leucocyte, lymphocyte, platelet and PCT were retrospectively collected. Results Compared with survival group, non-survival group was significantly higher in age, APACHEⅡscore, lactate, PCT, and significantly lower in lymphocyte and the number of UTI treatment ( P<0. 05 ) . Treatment with UTI was found to produce a significant decrease in death risk ( RR=0. 504, P=0. 008). UTI group and non-UTI group were similar in age, sex, APACHEⅡ score, lactate, leuco-cyte, lymphocyte, platelet and PCT. Dynamic changes on Day 6 and Day 1(the day when patients were diagnosed with severe sepsis) in APACHEⅡscore, lactate, leucocyte, lymphocyte, platelet were not significantly different in UTI group and non-UTI group. Decrease in PCT was more significant in UTI group than in non-UTI group ( P<0. 05 ) . Survival rate at 60 days was significantly higher in UTI group than in non-UTI group ( P<0. 05 ) . Moreo-ver, the survival analysis curves showed that patients in UTI group survived longer than patients in non-UTI group ( P<0. 05 ) . Conclusion The present study indicates that treatment with UTI can significantly reduce death risk in severe sepsis patients. Conventional therapy combined with UTI can significantly improve 60-day prognosis and reduce serum PCT level in severe sepsis patients.关键词
乌司他丁/脓毒症/降钙素原/APACHEⅡ评分Key words
ulinastatin/sepsis/procalcitonin/APACHEⅡ score分类
医药卫生引用本文复制引用
王伟,常平,李夏西,岑仲然..乌司他丁对严重脓毒症患者远期预后及体内降钙素原的影响[J].安徽医科大学学报,2016,51(5):744-747,4.基金项目
广东省科技计划项目(编号:2013B021800147) （编号:2013B021800147）
广州市科技项目(编号:2014J4100133) （编号:2014J4100133）
