重庆医学2016，Vol.45Issue(11)：1502-1504,1507,4.DOI:10.3969/j.issn.1671-8348.2016.11.018
甘精胰岛素联合二甲双胍对老年2型糖尿病患者氧化应激的影响
The effects of glargine combined metformin treatment on metabolism of free radicals in elderly patients with type 2 diabetes
摘要
Abstract
Objective To explore the effects of glargine combined metformin and repaglinide combined metformin treatment on metabolism of free radicals in elderly patients with type 2 diabetes(T2DM ) .Methods Selected 90 cases of elderly T2DM pa‐tients were divided into 2 groups:group A (glargine combined metformin treatment group) ,group B (repaglinide combined met‐formin treatment group) .Each group had 45 patients ,they were all treated for four weeks in antidiabetic therapy ,select 40 healthy people in physical examination center of hospital as controls .They were measured in patients with fasting plasma glucose (FPG) ,2h postprandial blood glucose(2hPG) ,malondialdehyde (MDA) ,glutathione peroxidase (GSH‐PX) ,8‐iso‐prostane (8‐iso‐PGF2a) , Hcy and so on ,before and after treatment .Results (1)Before treatment ,the FPG ,2hPG ,HbA1c ,MDA ,8‐iso‐PGF2a ,Hcy of group A and B were higher than the control group ,while the level of GSH‐PX was lower than the control group ,the difference was statis‐tically significant(P<0 .05);(2)After treatment ,the levels of FPG ,2hPG ,MDA ,8‐iso‐PGF2a ,Hcy were significantly reduced and the levels of GSH‐PX was significantly elevated in group A ,the differences were statistically significant (P<0 .05);(3)There were no obvious difference in reduce the levels of FPG ,2hPG and HbA1c between group A than group B(P>0 .05) ,While 8‐iso‐PGF2a , MDA ,Hcy of group A had a bigger decline rate than group B ,the GSH‐PX in group A increased more compared with group B ,the difference was statistically significant (P<0 .05) .Conclusion (1)There is a high oxidative stress state in elderly patients with T2DM ;(2)Both treatments could improve diabetics oxidative stress levels ,but glarginecombined metformin to reduce diabetics oxi‐dative stress is superior to repaglinide combined metformin .关键词
糖尿病 ,2型/老年/甘精胰岛素/瑞格列奈/二甲双胍/氧化应激Key words
diabetes mellitus ,type 2/the elderly/insulin glargine/repaglinide/metformin/oxidative stress分类
医药卫生引用本文复制引用
陈亮,姚志灵,刘文浩..甘精胰岛素联合二甲双胍对老年2型糖尿病患者氧化应激的影响[J].重庆医学,2016,45(11):1502-1504,1507,4.基金项目
山东省潍坊市卫生局科研项目（2011075）。 （）
