重庆医学2016，Vol.45Issue(12)：1647-1649,3.DOI:10.3969/j.issn.1671-8348.2016.12.020
老年高血压病与血浆Klotho、FGF23蛋白水平的相关性研究
Study on correlation between plasma Klotho,FGF23 protein level and senile hypertension
摘要
Abstract
Objective To explore the correlation between plasma Klotho and FGF23 levels with senile hypertension .Methods Totally 180 cases of hypertension aged more than 60 years old were selected as the research group and divided into the grade 1 hypertension group(60 cases) ,grade 2 hypertension group(60 cases) and grade 3 hypertension group(60 cases) .The age and pro‐portion of male to female were basically consistent .60 elderly people without hypertension were selected as the control group .The level of plasma Klotho and FGF23 protein were tested by ELISA .The lipid level was detected by the automatic biochemical analy‐zer .The detection results were compared with those in the control group for analyzing their correlation .Results Plasma Klotho protein level in each hypertension group was lower than that in the control group ,while plasma FGF23 protein level and BMI were significantly higher than those in the control group(P<0 .05) .With the blood pressure level increase ,plasma Klotho protein level was gradually decreased ,while FGF23 protein level was gradually increased .The negative correlation was found between plasma Klotho protein and FGF23 protein (r= -0 .282 ,P=0 .001) .Plasma Klotho protein and FGF23 protein had no obvious correlation with BMI (r= -0 .063 ,-0 .098 ,P>0 .05) .Conclusion Plasma Klotho protein and FGF23 protein levels have obvious correlation with the blood pressure level ,which may jointly participate in the occurrence and development of hypertension .关键词
Klotho蛋白/老年人/高血压/相关性Key words
Klotho protein/aged/hypertension/correlation分类
医药卫生引用本文复制引用
裴文楠,李宝善,蒋宜,唐渝平,李婷,周敏,柴李殷..老年高血压病与血浆Klotho、FGF23蛋白水平的相关性研究[J].重庆医学,2016,45(12):1647-1649,3.基金项目
重庆市卫生和计划生育委员会科研计划项目（2014-2-079，2013-2-104）；重庆市渝中区科技计划项目（20150139）。 （）
