南方医科大学学报2016，Vol.36Issue(5)：617-621,5.
SPLUNC1基因在人体组织中的表达分布特征
Expressions of short palate, lung and nasal epithelium clone 1 in different human tissues
摘要
Abstract
Objective To examine the expression patterns of short palate, lung and nasal epithelium clone 1 (SPLUNC1) gene in human tissues. Methods In situ hybridization was used to detect the expression of SPLUNC1 gene in 37 different human tissues. Results We found that SPLUNC1 gene was not expressed in squamous epithelial cells of the palate, epidermis, esophagus, or the esophagus-cardia junction, metaplastic squamous cells in the nasopharynx, trachea, or uterus cervix, or tumor cells of esophageal squamous cell carcinoma or lung squamous cell carcinoma. SPLUNC1 gene was not expressed in the single layer columnar epithelia cells in the stomach, gallbladder, jejunum, colon, endometrium, or uterus cervix. SPLUNC1 expression was detected mainly in pseudostratified columnar epithelial cells in the nasopharynx, trachea and bronchi, and was gradually down-regulated from the upper to lower end of the respiratory tract, but was not detected in the lung tissues. SPLUNC1 expression was detected not only in the duct and serous gland cells in the parotid and submandibular glands, but also in cells of submucosal serous glands in the nasopharynx and lung, but not in the cells of the mucosal glands. The parietal cells of the gastric submucosa and epithelial cells of the lobula and ducts of the mammary glands expressed SPLUNC1. The adenocarcinoma cells in the lung, stomach, colon, mammary gland, uterus endometrium and cervix showed strong expressions of SPLUNC1 gene. Conclusion SPLUNC1 expression is highly cell-specific in association with the cell functions.关键词
SPLUNC1/原位杂交/鳞状上皮/柱状上皮/浆液性腺体Key words
short palate/lung and nasal epithelium clone 1/in situ hybridization/squamous epithelial cells/columnar epithelia cells/serous glands引用本文复制引用
王爽,李文路,吕丽春,姚开泰..SPLUNC1基因在人体组织中的表达分布特征[J].南方医科大学学报,2016,36(5):617-621,5.基金项目
国家自然科学基金（81172242） Supported by National Natural Science Foundation of China （）
