南方医科大学学报2016，Vol.36Issue(5)：628-632,5.
超声造影评价右美托咪定对兔肾缺血/再灌注损伤时微循环灌注的影响
Effects of dexmedetomidine on microcirculatory perfusion in rabbits with renal ischemia/reperfusion injury:quantitative evaluation with contrast-enhanced ultrasound
摘要
Abstract
Objective To investigate the effects of dexmedetomidine on renal microcirculatory perfusion in rabbits with renal ischemia/reperfusion (I/R) injury rabbit by quantitative analysis of contrast-enhanced ultrasound (CEUS). Methods Twenty-four New Zealand rabbits were randomly divided into 3 groups (8 in each), including a control group, renal I/R injury group and dexmedetomidine group. In the latter two groups, the right kidney of the rabbits was resected and I/R injury was induced in the left kidney. In dexmedetomidine group, the rabbits received an intraperitoneal dose of 10 μg/kg dexmedetomidine 30 min before renal ischemia, and 24 h after reperfusion, the renal size and renal artery resistance (RI) were measured, and renal cortex perfusion was observed by CEUS. The time-to-peak intensity (TTP), peak signal intensity (PSI), gradient between start frame to peak frame (Grad) and area under the curve (AUC) were quantitatively analyzed using the time-intensity curves. Pathological changes of the kidney were also observed. Results Compared with the control group, the rabbits in I/R and dexmedetomidine groups showed distinct changes of the renal size with obvious renal pathologies. RI, PPT and AUC all increased, and PSI and Grad decreased significantly in I/R and dexmedetomidine groups (P<0.05). Compared with I/R group, obvious improvement of the renal size and renal pathologies were observed in dexmedetomidine group, which showed significantly decreased RI, PPT and AUC and increased PSI and Grad (P<0.05). Conclusion CEUS combined with the time-intensity curve parameters allows quantitative and dynamic analysis of the protective effects of dexmedetomidine on microcirculatory perfusion in rabbits with renal I/R injury.关键词
超声造影/右美托咪定/肾缺血/再灌注损伤/微循环灌注Key words
contrast-enhanced ultrasound/dexmedetomidine/renal ischemia/reperfusion injury/microcirculatory perfusion引用本文复制引用
斯妍娜,韩流,张媛,陈利海,徐亚杰,孙凡,潘笑笑,曾令清,鲍红光..超声造影评价右美托咪定对兔肾缺血/再灌注损伤时微循环灌注的影响[J].南方医科大学学报,2016,36(5):628-632,5.基金项目
国家自然科学基金（81401620）；南京市医学科技发展项目基金（YKK12085） Supported by National Natural Science Foundation of China (81401620) （81401620）
