广东医学2016，Vol.37Issue(5)：678-681,4.
胆管癌中垂体肿瘤转化基因和碱性成纤维细胞生长因子的表达及意义
Expression of pituitary tumor transforming gene and basic fibroblast growth factor and its relationship with clini-cal pathological characteristics of bile duct carcinoma
摘要
Abstract
Objective To investigate human pituitary tumor transforming gene ( PTTG ) and basic fibroblast growth factor ( b-FGF) expression in cholangiocarcinoma and their correlation , as well as relevant clinicopathological pa-rameters, for diagnosis and early treatment of cholangiocarcinoma .Methods 58 cases of cholangiocarcinoma tissue were collected as the observation group , and 20 cases of normal bile duct tissue from patients with gallstones were collected as the control group .The expression of PTTG and b -FGF in the two groups was detected by immunohistochemistry , and the results were studied and analyzed .Results The positive rate of PTTG and b -FGF was 81.03%and 74.14%, respec-tively.Positive expression rates in cholangiocarcinoma , were significantly higher than in the control group ( P<0.05). PTTG expression in cholangiocarcinoma was positively correlated with the expression of b -FGF.Conclusion High ex-pression of PTTG in cholangiocarcinoma induces extracellular secretion and high expression of b -FGF.Meanwhile, B-FGF also induces the expression of PTTG .High expression of PTTG and b-FGF is closely related to the biological behav-iors of cholangiocarcinoma .Expressions of PTTG and b -FGF in cholangiocarcinoma are positively correlated .Combined detection of PTTG and b -FGF can help determine the degree of malignancy , guide treatment and predict prognosis of cholangiocarcinoma .关键词
胆管癌/垂体肿瘤转化基因/碱性成纤维细胞生长因子/免疫组织化学Key words
cholangiocarcinoma/pituitary tumor transforming gene/basic fibroblast growth factor/immunohisto-chemistr引用本文复制引用
余健雄,陈国容..胆管癌中垂体肿瘤转化基因和碱性成纤维细胞生长因子的表达及意义[J].广东医学,2016,37(5):678-681,4.基金项目
广东省医学科研基金立项课题 （）
