广东医学2016，Vol.37Issue(6)：833-835,836,4.
首发未治疗的精神分裂症患者不同脑区葡萄糖代谢水平∗
Glucose metabolism in various brain regions in first episode drug-naive patients with schizophrenia
摘要
Abstract
Objective To investigate the basic mechanisms of the pathophysiology of schizophrenia by observing local glucose metabolism in various brain regions in first-episode patients with schizophrenia. Methods Relative regional cerebral glucose metabolism was measured with fluorine-18 deoxyglucose (18F-FDG) positron emission tomography (PET) scan in 18 patients with first-episode untreated schizophrenia who met the diagnostic criteria in the 10th edition of the international classification of diseases (ICD-10) and in 18 healthy individuals. PET data were analyzed using Statis-tical Parametric Mapping ( SPM) and paired t-tests. Regional cerebral glucose metabolism was compared between the two groups. Results Compared with the normal control group, patients with schizophrenia exhibited significant regional cere-bral glucose metabolic abnormalities including increases of glucose metabolism in the left inferotemporal gyrus and left tem-poral fusiform gyrus, decreases of glucose metabolism in the right inferoparietal lobule, right supramarginal gyrus, left in-feroparietal lobule, right postcentral gyrus and right supplementary motor area (P<0. 05). Conclusion A reciprocal glu-cose metabolism pattern is revealed untreated patients with schizophrenia, with enhanced glucose metabolism in the tempo-ral lobe and reduced glucose metabolism in the parietal lobe and the frontal lobe.关键词
精神分裂症/正电子发射断层扫描/脑葡萄糖代谢Key words
schizophrenia/PET ( positron emission tomography)/cerebral glucose metabolism引用本文复制引用
胡文生,肖頔,黎娟花,李淑云,史新冲,岳殿超..首发未治疗的精神分裂症患者不同脑区葡萄糖代谢水平∗[J].广东医学,2016,37(6):833-835,836,4.基金项目
广东省科技计划项目(编号:粤科规划[2011]112号) （编号:粤科规划[2011]112号）
