国际口腔医学杂志2016，Vol.43Issue(3)：318-324,7.DOI:10.7518/gjkq.2016.03.015
表观遗传在牙发生和牙再生中的作用及意义
Epigenetics in tooth development and its implication in tooth regeneration
摘要
Abstract
Epigenetics, mainly including DNA methylation and histone post-translational modification, is the heritable changes that are not caused by changes in the DNA sequence; this change also alters how genes are expressed. DNA methylation typically causes gene transcriptional silencing, whereas demethylation leads to transcription activation. A large number of covalent modifications on histone, such as different types, residues, and amount, will affect the inhibition or activation of gene expression. Epigenetic modifications play pivotal roles in organogenesis by controlling gene expression during cell fate determination and reprogramming. In the process of tooth development, complex orchestration between genetic and epigenetic programs regulates the spatiotemporal expression of cell proliferation-, differentiation-, and migration-related genes, and finally tooth formation. Exploring the molecular biology of epigenetic, together with the epigenetic findings in tooth development, is not only fundamental but also inspiring for tooth regeneration.关键词
牙发育/基因表达调控/表观遗传/牙再生Key words
tooth development/gene expression and regulation/epigenetics/tooth regeneration分类
生物科学引用本文复制引用
周晨,凌均棨..表观遗传在牙发生和牙再生中的作用及意义[J].国际口腔医学杂志,2016,43(3):318-324,7.基金项目
国家自然科学基金（81170932）；广东省领军人才专项经费（52000-3210002）This study was supported by the National Natural Science Foundation of China(81170932) and Special Talents Fund in Guangdong Province(52000-3210002) （81170932）
