国际口腔医学杂志2016，Vol.43Issue(3)：333-337,5.DOI:10.7518/gjkq.2016.03.018
骨硬化蛋白对牙骨质形成的影响及其机制
Effect of sclerostin on cementogenesis and its mechanism
摘要
Abstract
Sclerostin, a secreted glycoprotein with a C-terminal cysteine knot-like domain protein, is produced by the osteocytes and has anti-anabolic effects on bone formation. Sclerostin is an antagonist of Wnt signaling pathway by binding to low density lipoprotein receptor-related protein-5/6 receptors and prompting the phosphorylation of β-catenin. Cementum is a specialized substance covering the root of a tooth and a dynamic entity within the periodontium sustaining the firmness of the tooth. Sclerostin has been identified during cementogenesis, in which the underlying mechanism is still obscure. On this basis, providing a comprehensive insight into the interactional and reciprocal molecular mechanism between sclerostin and cementum may facilitate cementogenesis-related tooth development and regeneration.关键词
牙骨质/骨硬化蛋白/无翅型小鼠乳房肿瘤病毒整合位点家族-β-连环蛋白-信号转导通路/分子机制/矿化组织Key words
cementum/sclerostin/wingless-type mice mammary tumour virus integration site family-β-catenin-signal transduction pathway/molecular mechanism/mineralized tissues分类
生物科学引用本文复制引用
陈甜,白丁..骨硬化蛋白对牙骨质形成的影响及其机制[J].国际口腔医学杂志,2016,43(3):333-337,5.基金项目
国家自然科学基金（11172190，81371171）；高等学校博士学科专项科研基金（20130181110013）This study was supported by the National Natural Science Foundation of China(11172190, 81371171) and the Doctoral Program Foundation of Institution of Higher Education of China(20130181110013) （11172190, 81371171）
