国际口腔医学杂志2016，Vol.43Issue(3)：348-351,4.DOI:10.7518/gjkq.2016.03.021
变异链球菌groE操纵子及其表达与调控
ThegroE operon ofStreptococcus mutans with its expression and regulation
摘要
Abstract
Streptococcus mutans(S.mutans), as one of the primary cariogenic bacteria, can respond to several environmental stresses. This ability mainly depends on the translation and expression of variety of heat shock protein genes. groE operon, one of the best-studied heat shock genes, affects the metabolism of cells by translating the heat shock proteins, groES-groEL, which can mediate the folding, assembly, transport, and degradation of new or misfolding proteins. The groE operon locates in 1 834 692-1 832 649 sites, including a σA promoter, inverted repeat sequence(CIRCE), groES, groEL and a terminator. It is highly conserved, and can be induced to express by stress environment including heat, acid, ethanol and hydrogen peroxide. Both HrcA-CIRCE system and CtsR play a negative regulation role, without a clear mechanism. Studies, about the structure and regulation mechanism of S.mutans groE operon in a molecular level, help to further clarify the physiological process of cells, and lay the foundation for understanding the molecular mechanism of cells under stress and pathological conditions.关键词
变异链球菌/groE操纵子/热休克蛋白基因/调控Key words
Streptococcus mutans/groE operon/heat shock protein gene/regulation分类
生物科学引用本文复制引用
王一舟,张雅琪,牛雪微,张志民..变异链球菌groE操纵子及其表达与调控[J].国际口腔医学杂志,2016,43(3):348-351,4.基金项目
国家自然科学基金 （）
