国际口腔医学杂志2016，Vol.43Issue(3)：357-360,4.DOI:10.7518/gjkq.2016.03.023
转换蛋白2及其调节和生理病理作用
Role of transformer 2 regulation and its physiological and pathological significance
摘要
Abstract
The transformer(TRA)2 protein belongs to the serine/arginine-rich(SR) protein family. The protein possesses two homologs, namely, TRA2α and TRA2β. These homologs exhibit structures similar to those of the SR proteins but significantly differ in function. TRA2 is not necessarily implicated in composition splicing but plays an important role in selecting the splicing sites of precursor mRNA. Further studies found that in mammals, the TRA2 family protein plays a key role in many physiological and pathological, as well as disease occurrence and development, processes. Moreover, the abnormal splicing process of RNA molecules can cause disease or aggravate existing pathological problems. However, the relationship between TRA2 proteins and diseases remains to be completely understood. Additional energy and effort are required to achieve success in investigating disease causes and in developing treatments关键词
转换蛋白/前体mRNA剪接蛋白/生理病理作用/疾病防治Key words
transformer/precursor mRNA splicing protein/physiological and pathological effect/disease control分类
生物科学引用本文复制引用
宁毅,郑晓旭,孙睿..转换蛋白2及其调节和生理病理作用[J].国际口腔医学杂志,2016,43(3):357-360,4.基金项目
山西省自然科学基金（2011011037）This study was supported by the Natural Science Foundation of Shanxi Province(2011011037) （2011011037）
