国际口腔医学杂志2016，Vol.43Issue(3)：366-370,5.DOI:10.7518/gjkq.2016.03.025
沙利度胺在口腔黏膜病临床治疗实践中的安全性分析
Analysis of the safety of thalidomide in the treatment of oral mucosal diseases
摘要
Abstract
Thalidomide has been on the market for more than 60 years. It is currently used for the treatment of inflammatory and autoimmune diseases, including a variety of oral mucosal diseases. Due to its serious teratogenic effect, many oral medicine specialists are very cautious about the safety of thalidomide in the clinical application. To clarify its effect, especially on patients of childbearing age and children, we sum up the pharmacokinetics, mechanism and clinical studies of thalidomide. We hope that this review could provide oral medicine specialists with more comprehensive information on the clinical safety and effectiveness of thalidomide for the treatment of oral mucosal diseases.关键词
沙利度胺/药物安全性/口腔黏膜病/育龄期妇女/儿童Key words
thalidomide/drug safety/oral mucosal diseases/child-bearing period woman/pediatrics分类
医药卫生引用本文复制引用
宋韬,王冏珂,文静,陈谦明,曾昕..沙利度胺在口腔黏膜病临床治疗实践中的安全性分析[J].国际口腔医学杂志,2016,43(3):366-370,5.基金项目
国家自然科学基金（81472533）；国家卫生和计划生育委员会公益性行业专项基金（201502018）This study was supported by Natural Science Foundation of China(81472533) and Nonprofit Industry Research Sepecific Fund of National Health and Family Planning Commission of China(201502018) （81472533）
