临床与病理杂志2016，Vol.36Issue(4)：384-388,5.DOI:10.3978/j.issn.2095-6959.2016.04.007
MMP-2、MMP-9与溃疡性结肠炎患者肠黏膜通透性的相关性研究
The relationship between the expression of matrix metalloproteinases and intestinal mucosal permeability in patients with ulcerative colitis
吴崑 1严红丽 2穆敬平3
作者信息
- 1. 湖北省十堰市东汽公司花果医院内科，湖北 十堰 442000
- 2. 湖北医药学院附属东风医院儿童医疗中心儿科，湖北 十堰 442000
- 3. 湖北医药学院，湖北 十堰 442000
- 折叠
摘要
Abstract
Objective:To investigate the relationship between the expression of matrix metalloproteinases (MMPs) and intestinal mucosal permeability in patients with ulcerative colitis.Methods: A total of 50 UC patients and 30 healthy volunteers were enrolled in this study. hTe levels of MMP-2 and MMP-9 in the serum were assessed by ELISA. Detected the lactulose and mannitol in participants after they took orally the lactulose and mannitol test solution by HPLC and calculated the ratio of lactulose/mannitol.Results: hTe serum levels of MMP-2 and <br> MMP-9 in UC patients were significantly higher than that in healthy controls (t=13.843,P<0.001;t=14.165, P<0.001). hTe levels of MMP-2 and MMP-9 were correlated with the severity and extent of disease (P<0.001). hTe lactulose/mannitol ratio in UC patients was signiifcantly higher than in control group (t=9.803,P<0.001). hTe serum levels of MMP-2 and MMP-9 in UC patients were correlated with the change of intestinal mucosal permeability. hTe serum levels of MMP-2 and MMP-9 in UC group are signiifcantly increased, which is correlated with the change of intestinal mucosal permeability(r=0.832,P<0.001;r=0.847,P<0.001).Conclusion:The serum levels of MMP-2 and MMP-9 in UC patients are signiifcantly increased, which is correlated with the change of intestinal mucosal permeability.关键词
基质金属蛋白酶-2/基质金属蛋白酶-9/溃疡性结肠炎/肠黏膜通透性Key words
MMP-2/MMP-9/ulcerative colitis/intestinal mucosal permeability引用本文复制引用
吴崑,严红丽,穆敬平..MMP-2、MMP-9与溃疡性结肠炎患者肠黏膜通透性的相关性研究[J].临床与病理杂志,2016,36(4):384-388,5.
