临床与病理杂志2016，Vol.36Issue(4)：407-412,6.DOI:10.3978/j.issn.2095-6959.2016.04.012
ACE、ACE/ACE2对胰腺癌的临床诊断价值初探
Diagnosis value of ACE, ACE/ACE2 as tumor markers in pancreatic cancer
摘要
Abstract
Objective: To explore the clinical diagnostic value of serum ACE, ACE2, ACE/ACE2 in malignant tumors of digestive system.Methods: Serum levels of ACE, ACE2, ACE/ACE2 were detected by ELISA from 15 pancreatic cancer patients, 10 post-pancreatic operation patients, 10 CA199 elevated patients, 10 acute pancreatitis patients, and 10 healthy people, compared the pancreatic cancer group with the benign pancreatic disease and healthy group respectively.Results: ACE, ACE/ACE2 serum levels [(275.340±247.042), (0.482±0.398) pg/mL] in pancreatic cancer group were signiifcantly higher than benign pancreatic disease group and healthy people (P<0.01). ACE2 in <br> CA199 elevated group (628.343±114.383) pg/mL and acute pancreatitis patients (515.078±157.815) pg/mL were lower than healthy people (948.89±496.498) pg/mL (P<0.05). But there were no statistical difference between elevated CA199 group and pancreatitis group (P>0.05).Conclusion: Serum ACE, ACE/ACE2 had clinical value in the diagnosis of pancreatic cancer, which can be provided new methods for the diagnosis of pancreatic cancer.关键词
胰腺癌/ACE/ACE2/诊断Key words
pancreatic cancer/ACE/ACE2/diagnosis引用本文复制引用
王婧,赵磊,车娟娟,李卉惠,庞歆桥,吴军,马妮娜..ACE、ACE/ACE2对胰腺癌的临床诊断价值初探[J].临床与病理杂志,2016,36(4):407-412,6.基金项目
北京市医院管理局“青苗”计划专项经费资助(QML20150107)；北京市中医药科技发展资金项目资助(QN2015-08)；首都卫生发展科研专项基金资助(2016-4-1112)；首都医科大学基础-临床合作课题资助项目(14JL31)；首都医科大学附属北京友谊医院院启动基金资助(yyqdkt2014-10)。hTe work was supported by Administration of Hospitals’ Youth Programme (QML20150107) （QML20150107）
the Traditional Chinese Medicine Science and Technology Development Fund Project of Beijing (QN2015-08) （QN2015-08）
the Capital Health Research and Development of Special (2016-4-1112) （2016-4-1112）
the Capital University of Medical Sciences Foundation-Clinical Cooperation Projects Funded Projects (14JL31) （14JL31）
the Research Foundation of Beijing Friendship Hospital (yyqdkt2014-10), P. R. China （yyqdkt2014-10）
