华南农业大学学报2016，Vol.37Issue(3)：23-28,6.DOI:10.7671/j.issn.1001-411X.2016.03.004
猪伪狂犬病病毒新流行株主要糖蛋白的分子特征分析
Molecular characteristics of major glycoproteins of the novel pseudorabies virus causing a severe epidemic in China
摘要
Abstract
Objective] In order to study the genetic characteristics of the novel epidemic pseudorabies vi-rus ( PRV) .[Method]A PRV strain named PRV AH was isolated from a pig farm in Anhui Province , the phylogenetic tree was constructed and the glycoproteins gB ,gC,gD and gE of this strain were analyzed .[Result] PRV AH was very similar to an epidemic strain which had caused a severe PRV outbreak in China since 2011 , but was distantly related to Bartha or other foreign strains .Compared with Bartha and other foreign strains , all PRV strains in China had obvious deletions and insertions of continuous amino acids in the glycoproteins , and some mutations were found in the critical functional regions of the glyco-proteins .[Conclusion ]This study analyzes the genetic differences between the novel epidemic PRV strain and Bartha strain at the molecular level , which provides a theoretical basis for further clarification of the immunization failure of Bartha-K61 vaccine .关键词
伪狂犬病病毒/新流行株/糖蛋白/分子特征Key words
pseudorabies virus/novel epidemic strain/glycoprotein/molecular characteristics分类
农业科技引用本文复制引用
向柯宇,潘慧,吉艺宽,王雨,张宝石,罗永文,琚春梅..猪伪狂犬病病毒新流行株主要糖蛋白的分子特征分析[J].华南农业大学学报,2016,37(3):23-28,6.基金项目
国家自然科学基金 （）
