检验医学与临床2016，Vol.13Issue(9)：1174-1176,3.DOI:10.3969/j.issn.1672-9455.2016.09.009
子宫颈癌患者 Treg 及 Th 细胞因子测定的临床意义
The clinical significance of regulatory T cells,IFN-γ and IL-4 in patients of cervical cancer
摘要
Abstract
Objective To investigate the level of regulatory T cells ,IFN‐γand IL‐4 and in cervical cancer ,then to analyze the correlation with the occurrence of the disease .Methods 40 cervical cancer patients ,35 cervical intraep‐ithelial neoplasias ,20 cervicitis patients and 20 health controls were selected ,flow cytometry and enzyme‐linked im‐munosorbant assay were employed for the ratio of regulatory T cells and IL‐4 and IFN‐γ;analyze the correlation of Treg cells with IFN‐γ and IL‐4 .Results The ratio of regulatory T cells in cervical cancer was significantly higher than that in health controls ,cervicitis disease and CIN .The IFN‐γ concentration in cervical cancer was significantly lower than that in health controls and cervictis disease(P<0 .05) .IL‐4 concentration in the cervical cancer was sig‐nificantly higher than that in health controls ,the cervicitis disease and CIN(P<0 .05) .The level of Treg cells was negatively relevant to IFN‐γ( r= - 0 .291 ,P< 0 .05 ) and positively relevant to IL‐4 ( r= 0 .383 ,P< 0 .05 ) . Conclusion The high level of Treg cells may play a crucial role in the immune tolerance and cervical precancerous le‐sions progress to cervical cancer .With CIN progress to cervical cancer ,Th1/Th2 balance to the deviation from Th2 cells ,the Th1 subsets inhibition and Th2 subsets hyperthyroidism ,this imbalance was closely related to the occur‐rence of tumor .The regulatory T cells had some correlation with IFN‐γand IL‐4 ,Treg cells ,IFN‐γand IL‐4 may be involved in the pathogenesis of cervical cancer .关键词
子宫颈癌/调节性T细胞/IFN-γ/IL-4Key words
cervical cancer/regulatory T cell/IFN-γ/IL-4引用本文复制引用
谭玉洁,谢春霞,张惠,马莉..子宫颈癌患者 Treg 及 Th 细胞因子测定的临床意义[J].检验医学与临床,2016,13(9):1174-1176,3.基金项目
贵州省科技厅联合基金项目（黔科合字［2011］037号）。 （）
