检验医学与临床2016，Vol.13Issue(9)：1199-1201,3.DOI:10.3969/j.issn.1672-9455.2016.09.017
3种不同抗凝剂在 CRRT 治疗中抗凝疗效及安全性分析
Three different anticoagulants in the treatment of CRRT efficacy and safety analysis
摘要
Abstract
Objective To compare the curative effect of unfractionated heparin ,low molecular heparin ,sodium citrate three anticoagulants in CRRT anticoagulation effect and evaluate their security .Methods Totally 72 patients in the hospital treated by CRRT from January 2013 to August 2014 were taken as research materials ,double blind method were randomly divided into unfractionated heparin group (group A ) ,low molecular weight heparin group (group B)and sodium citrate group(C group) ,with 24 cases in each group .The anticoagulant effectiveness(blood fil‐ter with and without coagulation and blood filter life) ,safety(treatment before and after the APTT ,PLT ,Cre ,TB changes)and bleeding complications(within 48 hours of the femoral vein /jugular vein puncture point ,digestive tract , skin and mucous membrane events there is no bleeding)were compared in three groups .Results The anticoagulant effect of C group was significantly better than that of A and B two groups ,with statistical significance(P<0 .05) . The service life of A group was significantly lower than that of B and C two groups(P<0 .05) ,but the B and C two groups of blood filter service life compared ,statistical difference was not obvious(P>0 .05) .Before treatment ,A ,B , C three groups of patients with APTT ,PLT ,Cre ,BT comparison ,there was no significant statistical difference(P>0 .05) .After treatment ,the APTT group C was significantly higher(P>0 .05)compared with the two groups of B and A .After treatment ,There was no significant difference of PLT ,Cre ,BT indicators in B and C group(P>0 .05) , but was significantly higher than that of group A(P<0 .05);A group had 8 cases of bleeding complications and the incidence rate was 33 .3% .There were statistical significance when compared with group B and group C(P<0 .05) . Conclusion Sodium citrate and low molecular weight heparin has ideal effect in increasing blood filter life ,reducing hit and bleeding complications .The sodium citrate should be given priority to ensure the smooth progress of CRRT on the basis of principle of individual .关键词
普通肝素/低分子肝素/枸橼酸钠/CRRT/安全性Key words
unfractionated heparin/low molecular heparin/sodium citrate/CRRT/safety引用本文复制引用
邓毅,陈晓梅,向睿,梁颇..3种不同抗凝剂在 CRRT 治疗中抗凝疗效及安全性分析[J].检验医学与临床,2016,13(9):1199-1201,3.基金项目
重庆市卫生和计划生育委员会医学科学研究基金资助项目（2013-2-229）。 （）
